Molecular structure of Nε-(1-Carboxymethyl)-L-lysine, CAS Number: 5746-04-3
Nε-(1-Carboxymethyl)-L-lysine (CAS 5746-04-3)
See product citations (13)
Alternate Names:
N6-(Carboxymethyl)lysine
Application:
Nε-(1-Carboxymethyl)-L-lysine is a nonenzymatic chemical modification of lysine
CAS Number:
5746-04-3
Purity:
≥97%
Molecular Weight:
204.22
Molecular Formula:
C8H16N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Nε-(1-Carboxymethyl)-L-lysine is used to study the impact of glycation on protein-protein interactions and cellular signaling pathways. It is involved in regulating the MAPK cellular signaling pathways. Nε-(1-Carboxymethyl)-L-lysine is an advanced glycation end product (AGE),a product from oxidative modification of glycated proteins under conditions of oxidative stress. Notably, Nε-(1-Carboxymethyl)-L-lysine activates the membrane-bound receptor for AGEs (RAGE), thereby initiating signaling cascades involving MAPKs and NF-κB. Intriguingly, shortening of RAGE leads to the generation of a soluble protein that binds to Nε-(1-Carboxymethyl)-L-lysine, subsequently reducing its signaling effects.
Nε-(1-Carboxymethyl)-L-lysine (CAS 5746-04-3) References
- Isotope dilution ESI-LC-MS/MS for quantification of free and total Nε-(1-Carboxymethyl)-L-Lysine and free Nε-(1-Carboxyethyl)-L-Lysine: comparison of total Nε-(1-Carboxymethyl)-L-Lysine levels measured with new method to ELISA assay in gruel samples. | Tareke, E., et al. 2013. Food Chem. 141: 4253-9. PMID: 23993613
- Role of methylglyoxal in Alzheimer's disease. | Angeloni, C., et al. 2014. Biomed Res Int. 2014: 238485. PMID: 24734229
- Carbon nanotube-bilirubin oxidase bioconjugate as a new biofuel cell label for self-powered immunosensor. | Cheng, J., et al. 2014. Anal Chem. 86: 11782-8. PMID: 25371137
- Influence of home cooking conditions on Maillard reaction products in beef. | Trevisan, AJ., et al. 2016. Food Chem. 196: 161-9. PMID: 26593478
- Glycolysis-Derived Compounds From Astrocytes That Modulate Synaptic Communication. | Gonçalves, CA., et al. 2018. Front Neurosci. 12: 1035. PMID: 30728759
- Dietary and Plasma Carboxymethyl Lysine and Tumor Necrosis Factor-α as Mediators of Body Mass Index and Waist Circumference among Women in Indonesia. | Liman, PB., et al. 2019. Nutrients. 11: PMID: 31847322
- Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes. | Eckhardt, BA., et al. 2020. JCI Insight. 5: PMID: 32267250
- Development and Application of Mass Spectroscopy Assays for Nε-(1-Carboxymethyl)-L-Lysine and Pentosidine in Renal Failure and Diabetes. | O'Grady, KL., et al. 2020. J Appl Lab Med. 5: 558-568. PMID: 32445362
- Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus. | Khosla, S., et al. 2021. Nat Rev Endocrinol. 17: 685-697. PMID: 34518671
- Controlled Formation of Carboxymethyllysine in Bone Matrix through Designed Glycation Reaction. | Sroga, GE. and Vashishth, D. 2021. JBMR Plus. 5: e10548. PMID: 34761150
- Influence of Lactose on the Maillard Reaction and Dehydroalanine-Mediated Protein Cross-Linking in Casein and Whey. | Nielsen, SD., et al. 2022. Foods. 11: PMID: 35406984
- Selective transportation and energy homeostasis regulation of dietary advanced glycation end-products in human intestinal Caco-2 cells. | Wu, Y., et al. 2022. Food Chem. 391: 133284. PMID: 35640343
- Formation of volatile flavor compounds, maillard reaction products and potentially hazard substance in China stir-frying beef sao zi. | Bai, S., et al. 2022. Food Res Int. 159: 111545. PMID: 35940754
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nε-(1-Carboxymethyl)-L-lysine, 5 mg | sc-212438A | 5 mg | $156.00 | |||
Nε-(1-Carboxymethyl)-L-lysine, 10 mg | sc-212438 | 10 mg | $395.00 | |||
Nε-(1-Carboxymethyl)-L-lysine, 25 mg | sc-212438B | 25 mg | $550.00 | |||
Nε-(1-Carboxymethyl)-L-lysine, 50 mg | sc-212438C | 50 mg | $738.00 | |||
Nε-(1-Carboxymethyl)-L-lysine, 100 mg | sc-212438D | 100 mg | $1574.00 |