NCoA-3 Antibody (AC3): sc-56855

NCoA-3 Antibody (AC3) is a mouse monoclonal IgG1 antibody that detects NCoA-3 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). NCoA-3, also known as RAC3, ACTR, AIB-1, and p/CIP, plays a crucial role as a transcriptional coactivator in the steroid receptor family, facilitating the transcriptional activation of hormone-responsive genes. NCoA-3 is particularly significant due to its involvement in the regulation of gene expression in response to steroid hormones, thyroid hormones, and retinoic acids, which are vital for numerous physiological processes, including development, metabolism, and immune response. NCoA-3 is predominantly located in the nucleus, where NCoA-3 interacts with various nuclear receptors and transcription factors, enhancing their transcriptional activity. Elevated expression of NCoA-3 in estrogen receptor-positive ovarian and breast cancers underscores its importance in cancer biology, as NCoA-3 is required for the transcriptional activation of p300/CBP-dependent transcription factors, which are implicated in oncogenic processes. Anti-NCoA-3 antibody (AC3) is an essential tool for researchers studying the molecular mechanisms of hormone signaling and its implications in cancer and other diseases.

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NCoA-3 Antibody (AC3) References:

1. Association of NCOA3 polymorphisms with breast cancer risk.  |  Burwinkel, B., et al. 2005. Clin Cancer Res. 11: 2169-74. PMID: 15788663
2. NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells.  |  Wagner, M., et al. 2013. BMC Cancer. 13: 570. PMID: 24304549
3. A large-scale functional screen identifies Nova1 and Ncoa3 as regulators of neuronal miRNA function.  |  Störchel, PH., et al. 2015. EMBO J. 34: 2237-54. PMID: 26105073
4. Correlation of the osteoarthritis susceptibility variants that map to chromosome 20q13 with an expression quantitative trait locus operating on NCOA3 and with functional variation at the polymorphism rs116855380.  |  Gee, F., et al. 2015. Arthritis Rheumatol. 67: 2923-32. PMID: 26211391
5. Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3.  |  Uranishi, K., et al. 2016. Biochem Biophys Res Commun. 478: 1720-5. PMID: 27601327
6. NR5A2 synergizes with NCOA3 to induce breast cancer resistance to BET inhibitor by upregulating NRF2 to attenuate ferroptosis.  |  Qiao, J., et al. 2020. Biochem Biophys Res Commun. 530: 402-409. PMID: 32536370
7. Circ_0001667 knockdown blocks cancer progression and attenuates adriamycin resistance by depleting NCOA3 via releasing miR-4458 in breast cancer.  |  Cui, Y., et al. 2022. Drug Dev Res. 83: 75-87. PMID: 34227151
8. ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma.  |  Han, R., et al. 2022. Genes Chromosomes Cancer. 61: 645-652. PMID: 35521817
9. Estrogen-dependent activation of NCOA3 couples with p300 and NF-κB to mediate antiapoptotic genes in ER-positive breast cancer cells.  |  Wang, J. and Zhou, Z. 2023. Discov Oncol. 14: 28. PMID: 36853387
10. USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice.  |  Li, X., et al. 2023. Biol Direct. 18: 37. PMID: 37415159

The preferred NCoA-3 antibody is NCoA-3 Antibody (F-2): sc-5305.