Mucin 2/MUC2 Antibody (Ccp58): sc-7314

Mucin 2 Antibody (Ccp58) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mucin 2 in mouse, rat, and human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Mucin 2 antibody (Ccp58) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. Mucin 2 plays a crucial role in forming protective mucus layers in the gastrointestinal tract and respiratory system, essential for maintaining epithelial integrity and facilitating pathogen and debris clearance. Mucin 2 is primarily secreted by goblet cells and forms a key component of the mucus gel coating intestinal and airway epithelia, contributing to barrier function and immune defense. Dysregulation of Mucin 2 expression has been linked to various pathologies, including colonic tumors, highlighting its importance in both normal physiology and disease states. Mucin 2′s unique structure, characterized by extensive glycosylation and variable number of tandem repeats, allows interactions with various proteins and molecules, underscoring its significance in cellular signaling and tissue homeostasis.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Mucin 2/MUC2 Antibody (Ccp58) References:

1. N-linked oligosaccharides play a role in disulphide-dependent dimerization of intestinal mucin Muc2.  |  Bell, SL., et al. 2003. Biochem J. 373: 893-900. PMID: 12744721
2. The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region.  |  Gum, JR., et al. 1992. J Biol Chem. 267: 21375-83. PMID: 1400449
3. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines.  |  Mesquita, P., et al. 2003. J Biol Chem. 278: 51549-56. PMID: 14525978
4. The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells.  |  van der Sluis, M., et al. 2004. Biochem Biophys Res Commun. 325: 952-60. PMID: 15541382
5. Molecular cloning of cDNAs derived from a novel human intestinal mucin gene.  |  Gum, JR., et al. 1990. Biochem Biophys Res Commun. 171: 407-15. PMID: 2393399
6. Cloning and sequencing of a human pancreatic tumor mucin cDNA.  |  Lan, MS., et al. 1990. J Biol Chem. 265: 15294-9. PMID: 2394722
7. Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen.  |  Siddiqui, J., et al. 1988. Proc Natl Acad Sci U S A. 85: 2320-3. PMID: 2895474
8. Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium.  |  Borisova, MA., et al. 2020. Sci Rep. 10: 21135. PMID: 33273633
9. Deletion of mucin 2 induces colitis with concomitant metabolic abnormalities in mice.  |  Ye, J., et al. 2021. Am J Physiol Gastrointest Liver Physiol. 320: G791-G803. PMID: 33728986
10. MUC2 and related bacterial factors: Therapeutic targets for ulcerative colitis.  |  Yao, D., et al. 2021. EBioMedicine. 74: 103751. PMID: 34902790
11. Mucin Expression Profiles in Ulcerative Colitis: New Insights on the Histological Mucosal Healing.  |  Leoncini, G., et al. 2024. Int J Mol Sci. 25: PMID: 38339134
12. Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.  |  Pandey, P., et al. 1995. Cancer Res. 55: 4000-3. PMID: 7664271

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mucin 2/MUC2 Antibody (Ccp58) has 87 citations in a variety of scientific publications.

Primary antibodies like Anti-Mucin 2/MUC2 Antibody (Ccp58) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mucin 2/MUC2 Antibody (Ccp58) Specifications

Alternate Product Name: MUC2

Product Clone Name: Ccp58

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Mucin 2

Epitope Species: human

Product Reactivity/Detection: Mucin 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 87 citations in various scientific publications

Available Conjugates/Forms for Mucin 2/MUC2 Antibody (Ccp58): AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790