Mucin 2/MUC2 Antibody (B306.1): sc-59859

Mucin 2 Antibody (B306.1) is a mouse monoclonal IgG1 antibody that detects Mucin 2 in mouse, rat, and human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Mucin 2 plays a crucial role in maintaining the integrity of epithelial surfaces, particularly in the intestines and airways, where Mucin 2 forms a protective mucus layer that traps pathogens and particulates, thereby preventing infection and inflammation. Mucin 2 is vital for gut health, as Mucin 2 not only facilitates the movement of food through the digestive tract but also serves as a barrier against harmful microorganisms. Aberrant expression of Mucin 2 has been linked to various colonic tumors, highlighting Mucin 2′s importance in both normal physiology and disease states. Anti-Mucin 2 antibody (B306.1) is particularly valuable for researchers studying gastrointestinal disorders and cancer, as Mucin 2 monoclonal antibody (B306.1) allows for the visualization and analysis of Mucin 2 expression patterns in tissue samples, providing insights into its role in health and disease.

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Mucin 2/MUC2 Antibody (B306.1) References:

1. Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity.  |  Hartmann, P., et al. 2016. Am J Physiol Gastrointest Liver Physiol. 310: G310-22. PMID: 26702135
2. Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling.  |  Hsu, HP., et al. 2017. Sci Rep. 7: 5823. PMID: 28725043
3. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response.  |  Gao, X., et al. 2018. Proc Natl Acad Sci U S A. 115: E2960-E2969. PMID: 29531080
4. Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer.  |  Bademler, S., et al. 2019. Biomolecules. 9: PMID: 30682816
5. Computational studies of mucin 2 and its interactions with thiolated chitosans: a new insight for mucus adhesion and drug retention.  |  Cavalcanti da Silveira, CO., et al. 2020. J Biomol Struct Dyn. 38: 1479-1487. PMID: 31014188
6. Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium.  |  Borisova, MA., et al. 2020. Sci Rep. 10: 21135. PMID: 33273633
7. A Mediterranean-like fat blend protects against the development of severe colitis in the mucin-2 deficient murine model.  |  Haskey, N., et al. 2022. Gut Microbes. 14: 2055441. PMID: 35471119
8. Clinicopathological Factors Affecting Mucin 1, Mucin 2, and Mucin 5AC Staining in Patients who Underwent Resection for Colorectal Cancer.  |  Anuk, T., et al. 2023. J Coll Physicians Surg Pak. 33: 335-340. PMID: 36945166
9. Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer.  |  Oosterlinck, B., et al. 2023. Microbiome. 11: 86. PMID: 37085819
10. Low Expression of Mucin 2, High Expression of Mucin 13, and High Expression of Nuclear Factor Kappa-Light-Enhancer of Activated B Cells were Significant Pathways in Colorectal Cancer Development.  |  Mulyawan, IM. 2023. Asian Pac J Cancer Prev. 24: 1119-1123. PMID: 37116131

The preferred Mucin 2/MUC2 antibody is Mucin 2/MUC2 Antibody (Ccp58): sc-7314.