(−)-Bicuculline methochloride (−)-Bicuculline methochloride is a water-soluble GABAA antagonist.

(−)-Bicuculline methochloride (CAS 53552-05-9)

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Applicazione: (−)-Bicuculline methochloride is a water-soluble GABAA antagonist
Numero CAS: 53552-05-9
Peso molecolare: 417.84
Formula molecolare: C21H20ClNO6
Informazioni supplementari: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
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(−)-Bicuculline methochloride is a methochloride salt of (+)-bicuculline. This compound is a water-soluble GABA Receptor (GABAA) antagonist. (−)-Bicuculline methochloride is more stable than bicuculline, and non-GABA receptor-mediated actions are reported.


Referenze

1. Kemp, J.A., et al. 1986. Br. J. Pharmacol. 87: 677-784. PMID: 3011168
2. Seutin, V., et al. 1997 Neuropharmacology. 36: 1653-1657. PMID: 9517436
3. Seutin, V., et al. 1999. Trends Pharmacol Sci. 20: 268-270. PMID: 10390643

Stato fisico :
Solid
Solubilità :
Soluble in water (100 mM).
CONSERVAZIONE :
Store at room temperature
Indice di rifrazione :
n20D 1.67 (Predicted)
IC50 :
Small conductance calcium-activated potassium channel protein 3: IC50 = 7 µM (rat)
Ki Data :
Small conductance calcium-activated potassium channel protein 3: Ki= 4.4 µM (rat)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
RTECS :
LV0909840
PubChem CID :
Numero MDL :
MFCD00055233
SMILES :
C[N+]1(CCC2=CC3=C(C=C2[[email protected]]1[[email protected]]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3)C.[Cl-]

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