Mi2-β Antibody (H-8): sc-373820
- Mi2-β Antibody (H-8) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1887-1909 at the C-terminus of Mi2-β of human origin
- recommended for detection of Mi2-β of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and porcine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mi2-β Antibody (H-8). This work is in progress.
Mi2-β Antibody (H-8) is a mouse monoclonal IgM antibody that detects Mi2-β in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mi2-β (H-8) antibody recognizes a crucial component of the mSin3 corepressor complex, which plays a significant role in gene expression regulation by mediating histone deacetylation. Mi2-β (H-8) monoclonal antibody targets a protein primarily located in the nucleus, where Mi2-β interacts with other proteins to remodel chromatin structure, influencing transcriptional activity. Mi2-β′s ability to recruit histone deacetylases, such as HDAC1 and HDAC2, is vital for maintaining the balance between gene activation and repression, making Mi2-β essential for proper cellular function and development. Dysregulation of Mi2-β and associated complexes can lead to various diseases, including cancer, highlighting the importance of studying Mi2-β in understanding transcriptional regulation and disease implications. anti-Mi2-β antibody (H-8) provides a reliable tool for researchers investigating gene regulation and chromatin dynamics.
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Mi2-β Antibody (H-8) References:
- NuRD complex component Mi-2beta binds to and represses RORgamma-mediated transcriptional activation. | Johnson, DR., et al. 2004. Biochem Biophys Res Commun. 318: 714-8. PMID: 15144897
- Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription. | Shimono, K., et al. 2005. J Biol Chem. 280: 39436-47. PMID: 16186106
- Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. | Ramirez-Carrozzi, VR., et al. 2006. Genes Dev. 20: 282-96. PMID: 16452502
- The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. | Kashiwagi, M., et al. 2007. Development. 134: 1571-82. PMID: 17360773
- Mi2β is required for γ-globin gene silencing: temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in β-YAC transgenic mice. | Costa, FC., et al. 2012. PLoS Genet. 8: e1003155. PMID: 23284307
- Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells. | Amaya, M., et al. 2013. Blood. 121: 3493-501. PMID: 23444401
- O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter. | Zhang, Z., et al. 2016. J Biol Chem. 291: 15628-40. PMID: 27231347
- Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation. | Yoshida, T., et al. 2019. Genes Dev. 33: 763-781. PMID: 31123064
- Functional interactions between Mi-2β and AP1 complexes control response and recovery from skin barrier disruption. | Shibata, S., et al. 2020. J Exp Med. 217: PMID: 31834931
- Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation. | Li, C., et al. 2024. Nat Commun. 15: 2163. PMID: 38461299
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mi2-β Antibody (H-8) | sc-373820 | 200 µg/ml | $322.00 | |||
Mi2-β (H-8) Neutralizing Peptide | sc-373820 P | 100 µg/0.5 ml | $69.00 |