MG-132 [Z-Leu- Leu-Leu-CHO] CAS: 133407-82-6
MF: C26H41N3O5
MW: 475.62

MG-132 [Z-Leu- Leu-Leu-CHO] (CAS 133407-82-6)

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MG-132 [Z-Leu- Leu-Leu-CHO] is rated 5.0 out of 5 by 2.
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Nomi alternativi: MG-132 [Z-Leu- Leu-Leu-CHO] also known as (S)-MG132; Z-LLL-al; Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal; N-CBZ-leucine-leucine-leucinal; Z-Leu-Leu-Leu-CHO; Z-Leu-Leu-Leu-al; MG132; MG-132; S)-MG132
Applicazione: MG-132 [Z-Leu- Leu-Leu-CHO] is a proteasome and NF-κB inhibitor which is used as a tool for perturbing the proteasome-regulated degradation of intr
Numero CAS: 133407-82-6
Purezza: >98%
Peso molecolare: 475.62
Formula molecolare: C26H41N3O5
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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MG-132 [Z-Leu-Leu-Leu-CHO] is a potent, reversible, and cell-permeable proteasome inhibitor. MG-132 [Z-Leu- Leu-Leu-CHO] is used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation, presenting broad relevance for aldehydic proteasome inhibitors of this type. For instance, MG-132 suppresses NF-κB activation (at 10 μM) by preventing IκB degradation (IC50=3 μM), which blocks the transcription factor from providing chemoresistance to cancer cells. Also, MG-132 has been shown to prevent beta-secretase cleavage of amyloid precursor protein (APP). Additionally, MG-132 is an inhibitor of 26S Proteasome and calpain, as well as, an activator of JNK1, c-Jun and c-Fos.

Related products include sc-351846 (sc-351846).


Referenze

1. Lee, D.H. and Goldberg, A.L. 1998. Trends Cell Biol. 8: 397-403. PMID: 9789328

2. Arlt, A., et al. 2001. Oncogene. 20: 859-868. PMID: 11314019

3. Steinhilb, M. L., et al. 2001. J Biol Chem. 276(6):4476-4484. PMID: 11084038

4. Elliott, P.J., et al. 2003. J. Mol. Med. 81: 235-245. PMID: 12700891

5. Vivier, M., et al. 2008. J. Med. Chem. 51: 1043-1047. PMID: 18237109

6. Ye, X. et al. 2014. PLoS Pathog. 10(4): e1004070. PMID: 24722419

Stato fisico :
Solid
Sequenza :
Z-Leu-Leu-Leu-CHO
Solubilità :
Soluble in ethanol (100 mM), and DMSO (100 mM).
CONSERVAZIONE :
Store at -20° C
Attività ottica :
α20D -65.5, c = 1 in chloroform
IC50 :
NF-κB activation: IC50 = 3 µM; Suc-LLVY-AMC cleaving activity of proteasome: IC50 = 0.85 µM; Z-LLL-AMC cleaving activity of proteasome: IC50 = 0.1 µM; calpain: IC50 = 1.2 µM; IκBα degradation: IC50 = 3 µM
Ki Data :
proteasome: Ki= 4 nM
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
OH2824610
PubChem CID :
Numero MDL :
MFCD00674886
SMILES :
CC(C)C[[email protected]@H](C=O)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]](CC(C)C)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

CERTIFICATO DI ANALISI

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MG-132 [Z-Leu- Leu-Leu-CHO] (CAS 133407-82-6)  Citazioni prodotti

Vedi quanti altri hanno usato MG-132 [Z-Leu- Leu-Leu-CHO] (CAS 133407-82-6). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 118 totali

PMID: # 34004371  Scholtès, GK.|Sawyer, AM.|Vaca, CC.|Clerc, I.|Roh, M.|Song, C.|D'Aquila, RT.| et al. 2021. Transl Res.

PMID: # 33637846  Chandrasekaran, S.|Schneps, CM.|Dunleavy, R.|Lin, C.|DeOliveira, CC.|Ganguly, A.|Crane, BR.| et al. 2021. Commun Biol. 4: 249.

PMID: # 34029592  Gaborit, B.|Govers, R.|Altié, A.|Brunel, JM.|Morange, P.|Peiretti, F.| et al. 2021. J Biol Chem. 100818.

PMID: # 33922657  Tseng, WC.|Chen, CY.|Chern, CY.|Wang, CA.|Lee, WC.|Chi, YC.|Cheng, SF.|Kuo, YT.|Chiu, YC.|Tseng, ST.|Lin, PY.|Liou, SJ.|Li, YC.|Chen, CC.| et al. 2021. Int J Mol Sci. 22:

PMID: # 31676796  García-Pastor, C.|Benito-Martínez, S.|Moreno-Manzano, V.|Fernández-Martínez, AB.|Lucio-Cazaña, FJ.| et al. 2019. Sci Rep. 9: 15868.

PMID: # 31078367  Joa, H. et al. 2019. Phytomedicine. 152938.

PMID: # 30821592  Peng, M.|Wang, J.|Tian, Z.|Zhang, D.|Jin, H.|Liu, C.|Xu, J.|Li, J.|Hua, X.|Xu, J.|Huang, C.|Huang, C.| et al. 2019. Autophagy.

PMID: # 31086178  Dabral, S. et al. 2019. Nat Commun. 10: 2130.

PMID: # 30849304  Rosas, MG. et al. 2019. Biochem. Pharmacol. 163: 362-370.

PMID: # 31052354  Yang, IH. et al. 2019. Molecules. 24:

Ciatazioni 1 a10 di 118 totali
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