Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Tumor cells that are insensitive to anticancer drugs often have a multidrug-resistant (MDR) phenotype. Proteins associated with this phenomenon are transport-associated proteins such as P-glycoprotein, multidrug resistance protein 1, lung resistance-related protein (LRP) and breast cancer resistance protein (BCRP). The LRP protein, which is identified as the major vault protein (MVP), is overexpressed in various multidrug-resistant cancer cell lines and clinical samples. The promoter of LRP is TATA-less; contains an inverted CCAAT-box and a Sp1 site located near a p53 binding motif. LRP has two alternative splice variants, which differ from each other within the 5'-leader. The long-LRP isoform is ubiquitously expressed and represents an almost constant portion of the total LRP mRNA in many different normal tissues. LRP is the major component of the multimeric ribonucleoprotein complexes, with several copies of an untranslated RNA, which has been shown to transport along cytoskeletal-based cellular tracks. In conclusion, LRP protein mediates drug resistance, perhaps via a transport process.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
I am using LRP (42): sc-135975 for immunofluorescence, what dilution of this antibody should I use?
Richiesta da: Randy McDonald
Thank you for your question. We recommend a starting dilution of 1:50. However, optimal antibody concentration should be determined by titration. Please find our full immunofluorescence protocol here:
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn