LP 922056 (CAS 1365060-22-5)
Alternate Names:
2-[(6-Chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)thio]acetic acid
CAS Number:
1365060-22-5
Molecular Weight:
300.78
Molecular Formula:
C11H9ClN2O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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LP 922056 (CAS 1365060-22-5) References
- NOTUM inhibition increases endocortical bone formation and bone strength. | Brommage, R., et al. 2019. Bone Res. 7: 2. PMID: 30622831
- Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen. | Atkinson, BN., et al. 2019. Medchemcomm. 10: 1361-1369. PMID: 31534655
- An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent. | Willis, NJ., et al. 2019. Beilstein J Org Chem. 15: 2790-2797. PMID: 31807213
- Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. | Mahy, W., et al. 2020. J Med Chem. 63: 9464-9483. PMID: 32787107
- A Mild Method for Making MIDA Boronates. | Kelly, AM., et al. 2020. Org Lett. 22: 9408-9414. PMID: 32841037
- Age-related changes in intestinal immunity and the microbiome. | Walrath, T., et al. 2021. J Leukoc Biol. 109: 1045-1061. PMID: 33020981
- 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit. | Mahy, W., et al. 2020. J Med Chem. 63: 12942-12956. PMID: 33124429
- Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling. | Bayle, ED., et al. 2021. J Med Chem. 64: 4289-4311. PMID: 33783220
- Small-molecule inhibitors of carboxylesterase Notum. | Zhao, Y., et al. 2021. Future Med Chem. 13: 1001-1015. PMID: 33882714
- NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. | Flanagan, DJ., et al. 2021. Nature. 594: 430-435. PMID: 34079124
- Wnt signaling activation: targets and therapeutic opportunities for stem cell therapy and regenerative medicine. | Bonnet, C., et al. 2021. RSC Chem Biol. 2: 1144-1157. PMID: 34458828
- Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. | Steadman, D., et al. 2022. J Med Chem. 65: 562-578. PMID: 34939789
- Therapeutic Potential of Naturally Occurring Small Molecules to Target the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer. | Oliveira, LFS., et al. 2022. Cancers (Basel). 14: PMID: 35053565
- Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. | Willis, NJ., et al. 2022. J Med Chem. 65: 7212-7230. PMID: 35536179
Inhibitor of:
LPPR2, SphK2, and SREBP-2.Activator of:
Wnt.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LP 922056, 5 mg | sc-507098 | 5 mg | $165.00 | |||
LP 922056, 25 mg | sc-507098A | 25 mg | $700.00 |