Lisinopril is an inhibitor of ACE (angiotensin-converting enzyme), which removes the C-terminal dipeptide from angiotensin I to form a powerful vasoconstrictor, angiotensin II. ACE is a key regulator of the renin-angiotensin system(RAAS). This compound has an IC50 of 1.2 nM.
1 Zaman, M.A., Oparil, S., Calhoun, D.A. Drugs targeting the renin-angiotensin-aldosterone system. Nature Reviews Drug Discover 1 621-636 (2002). 2 Patchett, A.A., Harris, E., Tristram, E.W., et al. A new class of angiotensin-converting enzyme inhibitor