L-755,507 CAS: 159182-43-1
MF: C30H40N4O6S
MW: 584.73

L-755,507 (CAS 159182-43-1)

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Nomi alternativi: L-755,507 is also known as a selective β3-adrenergic receptor partial agonist.
Applicazione: L-755,507 is a very potent, selective β3-adrenergic receptor partial agonist and enhancer of CRISPR-mediated HDR efficiency.
Numero CAS: 159182-43-1
Purezza: ≥97%
Peso molecolare: 584.73
Formula molecolare: C30H40N4O6S
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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L-755,507 is a very potent and selective β3-adrenergic receptor partial agonist, selective over both β1- and β2-adrenoceptor binding. In fact, L-755,507 displays more than 440-fold selectivity for β3- over β1- and β2-adrenoceptors (EC50s = 580 and >10,000 nM, respectively). L-755,507 is used to assess β3 agonists. To identify signaling pathways activated through β3-adrenergic receptors, L-755,507 can be used.


Referenze

1. Parmee, E.R., Ok, H.O., Candelore, M.R., Tota, L., Deng, L., Strader, C.D., Wyvratt, M.J., Fisher, M.H. and Weber, A.E. 1998. Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist. Bioorg. Med. Chem. Lett. 8(9): 1107-1112. PMID: 9871717

2. Fisher, M.H., Amend, A.M., Bach, T.J., Barker, J.M., Brady, E.J., Candelore, M.R., Carroll, D., Cascieri, M.A., Chiu, S.H., Deng, L., Forrest, M.J., Hegarty-Friscino, B., Guan, X.M., Hom, G.J., Hutchins, J.E., Kelly, L.J., Mathvink, R.J., Metzger, J.M., Miller, R.R., Ok, H.O., Parmee, E.R., Saperstein, R., Strader, C.D., Stearns, R.A. and MacIntyre, D.E. 1998. A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. J. Clin. Invest. 101(11): 2387-2393. PMID: 9616210

3. Yu, C. et al. 2015. Cell Stem Cell. 16(2): 142-147. PMID: 25658371

Stato fisico :
Solid
Solubilità :
Soluble to 100 mM in DMSO and to 100 mM in Ethanol
CONSERVAZIONE :
Desiccate at room temperature
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
SMILES :
CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNC[[email protected]@H](COC3=CC=C(C=C3)O)O

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L-755,507 (CAS 159182-43-1)  Citazioni prodotti

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PMID: # 30355591  Boel, A.|De Saffel, H.|Steyaert, W.|Callewaert, B.|De Paepe, A.|Coucke, PJ.|Willaert, A.| et al. 2018. Dis Model Mech. 11:

PMID: # 29321585  Ishida, K.|Xu, H.|Sasakawa, N.|Lung, MSY.|Kudryashev, JA.|Gee, P.|Hotta, A.| et al. 2018. Sci Rep. 8: 310.

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