Integrin α2/ITGA2/CD49b Antibody (P4B4): sc-53506

Integrin α2 Antibody (P4B4) is a mouse monoclonal IgG2b antibody that detects Integrin α2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Integrin α2 plays a crucial role in mediating cell adhesion to collagen, which is essential for maintaining tissue integrity and facilitating communication between cells and the extracellular matrix. Integrin α2 is primarily located on the surface of platelets and various other cell types, where anti-Integrin α2 antibody (P4B4) can detect interactions with collagen fibers, promoting platelet aggregation and wound healing. Integrin α2′s ability to bind collagen not only aids in the structural support of tissues but also initiates intracellular signaling pathways that influence cell behavior, including migration and survival. By understanding the function and significance of Integrin α2, researchers can gain insights into various physiological processes and potential therapeutic targets for conditions related to impaired cell adhesion and tissue repair. Integrin α2 monoclonal antibody (P4B4) is an invaluable tool for studying these mechanisms in human samples, providing a reliable means to explore the intricate roles of integrins in health and disease.

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Integrin α2/ITGA2/CD49b Antibody (P4B4) References:

1. Integrin alpha2 and extracellular signal-regulated kinase are functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cells.  |  Sawhney, RS., et al. 2003. J Biol Chem. 278: 19861-9. PMID: 12657625
2. An angiogenesis inhibitor E7820 shows broad-spectrum tumor growth inhibition in a xenograft model: possible value of integrin alpha2 on platelets as a biological marker.  |  Semba, T., et al. 2004. Clin Cancer Res. 10: 1430-8. PMID: 14977846
3. Crystal structure of EMS16 in complex with the integrin alpha2-I domain.  |  Horii, K., et al. 2004. J Mol Biol. 341: 519-27. PMID: 15276841
4. The intermediate filament protein vimentin binds specifically to a recombinant integrin alpha2/beta1 cytoplasmic tail complex and co-localizes with native alpha2/beta1 in endothelial cell focal adhesions.  |  Kreis, S., et al. 2005. Exp Cell Res. 305: 110-21. PMID: 15777792
5. Platelet glycoprotein I(b)alpha and integrin alpha2 beta1 polymorphisms: gene frequencies and linkage disequilibrium in a population diversity panel.  |  Di Paola, J., et al. 2005. J Thromb Haemost. 3: 1511-21. PMID: 15978109
6. Down-regulation of integrin alpha2 surface expression by mutant epidermal growth factor receptor (EGFRvIII) induces aberrant cell spreading and focal adhesion formation.  |  Ning, Y., et al. 2005. Cancer Res. 65: 9280-6. PMID: 16230389
7. Competitive interactions of collagen and a jararhagin-derived disintegrin peptide with the integrin alpha2-I domain.  |  Lambert, LJ., et al. 2008. J Biol Chem. 283: 16665-72. PMID: 18417478
8. Integrin α2-deficient mice provide insights into specific functions of collagen receptors in the kidney.  |  Girgert, R., et al. 2010. Fibrogenesis Tissue Repair. 3: 19. PMID: 20860797
9. Platelet adhesion to decorin but not collagen I correlates with the integrin α2 dimorphism E534K, the basis of the human platelet alloantigen (HPA)-5 system.  |  Kunicki, TJ., et al. 2012. Haematologica. 97: 692-5. PMID: 22133774
10. EZH2 is regulated by ERK/AKT and targets integrin alpha2 gene to control Epithelial-Mesenchymal Transition and anoikis in colon cancer cells.  |  Ferraro, A., et al. 2013. Int J Biochem Cell Biol. 45: 243-54. PMID: 23116973

The preferred Integrin α2/ITGA2/CD49b antibody is Integrin α2/ITGA2/CD49b Antibody (C-9): sc-74466.