Ilimaquinone CAS: 71678-03-0
MF: C22H30O4
MW: 358.47
An ADP-ribosylation factor (ARF) and β-COP to the Golgi membrane inhibitor.

Ilimaquinone (CAS 71678-03-0)

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Sinonimo: 3-[(Decahydro-1β,2β,4αβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone;Imaquinone
Applicazione: An ADP-ribosylation factor (ARF) and β-COP to the Golgi membrane inhibitor
Numero CAS: 71678-03-0
Purezza: ≥98%
Peso molecolare: 358.47
Formula molecolare: C22H30O4
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Ilimaquinone is a natural marine metabolite shown to have antiinflammatory, antimicrobial, and antimitotic properties. Ilimaquinone has also been described to block diptheria toxin and the cytotoxicity of ricin. Golgi membrane studies reveal that exposure to ilimaquinone results in the formation of vesiculated Golgi membranes and blockage of the secretory pathway, which can be reversed with the removal of ilimaquinone. Additionally, ilimaquinone has been shown to block the association of the ADP-ribosylation factor (ARF) and β-COP to the Golgi membrane, and depolarize cytoplasmic microtubules. Further studies report that the vesiculation of Golgi membranes through Ilimaquinone takes place by the activation of heterotrimeric G proteins. Biochemical assays from HIV studies suggest that ilimaquinone belongs to a group of marine metabolites with anti-HIV activity. Ilimaquinone studies suggest that it has the ability to induce anti-proliferative affects through GADD153-mediated pathway modifications.


Referenze

1. Takizawa, P.A., et al. 1993. Cell. 73: 1079-1090. PMID: 8513494
2. Veit, B., et al. 1993. J. Cell Biol. 122: 1197-1206. PMID: 8104190
3. Jamora, C., et al. 1997. Cell. 91: 617-626. PMID: 9393855
4. Dinter, A., et al. 1998. Histochem. Cell Biol. 109: 571-590. PMID: 9681636
5. Radeke, H.S., et al. 1999. Chem. Biol. 6: 639-647. PMID: 10467129
6. Tziveleka, L.A., et al. 2003. Curr Top Med Chem. 3: 1512-1535. PMID: 14529524
7. Lu, P.H., et al. 2007. Eur. J. Pharmacol. 556: 45-54. PMID: 17140562

Stato fisico :
Solid
Solubilità :
Soluble in DMSO (25 mg/ml), and ethanol (25 mg/ml).
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
204.22° C (Predicted)
Punto di ebollizione :
~478.4° C at 760 mmHg (Predicted)
Densità :
~1.1 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.55
IC50 :
P388: IC50 = 0.2 ug/ml (Mus musculus); A549: IC50 = 0.4 ug/ml (human); A2780: IC50 = 10.9 µM (human); Adenosylhomocysteinase: IC50 = 40 µM (human)
Valori pK :
pKa: 2.92
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
72291
Indice Merck :
14: 4898
Numero MDL :
MFCD00274432
SMILES :
C[[email protected]]1CC[[email protected]]2([[email protected]]([[email protected]]1(C)CC3=C(C(=O)C=C(C3=O)OC)O)CCCC2=C)C

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Ilimaquinone  Citazioni prodotti

Vedi quanti altri hanno usato Ilimaquinone. Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a1 di 1 totali

PMID: # 27281477  Massarweh, A. et al. 2016. J. Lipid Res. 57: 1477-91.

Ciatazioni 1 a1 di 1 totali
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