IFN- alpha 2 Antibody (N39): sc-57220

IFN-α2 Antibody (N39) is a mouse monoclonal IgG1 antibody that detects IFN-α2 in human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). IFN-α2, a member of the type I interferon family, plays a crucial role in the immune response by inducing antiviral activity and modulating the immune system. This cytokine is primarily produced by leukocytes in response to viral infections and is essential for the activation of immune cells, including natural killer cells and macrophages, which are vital for controlling viral replication and tumor growth. The importance of IFN-α2 extends to clinical applications in treating various malignancies, myelodysplastic syndromes, and autoimmune diseases. Additionally, IFN-α2 undergoes post-translational modifications, such as glycosylation, which can influence stability, activity, and interaction with receptors, thereby affecting overall efficacy as a therapeutic agent. The IFN-α receptor, which interacts with IFN-α2, is a multisubunit complex that mediates the diverse biological effects of type I interferons, highlighting the significance of anti-IFN-α2 antibody (N39) in research and clinical applications.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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IFN- alpha 2 Antibody (N39) References:

1. A promoter polymorphism in the interferon alpha-2 gene is associated with the clinical presentation of hepatitis B.  |  Song, le H., et al. 2006. Mutat Res. 601: 137-43. PMID: 16920161
2. Three human interferon-alpha 2 subvariants disclose structural and functional differences.  |  von Gabain, A., et al. 1990. Eur J Biochem. 190: 257-61. PMID: 1694761
3. Study of aggregation, denaturation and reduction of interferon alpha-2 products by size-exclusion high-performance liquid chromatography with fluorescence detection and biological assays.  |  Diress, A., et al. 2010. J Chromatogr A. 1217: 3297-306. PMID: 19931086
4. Treatment of flat or accuminata condylomata of the female genital tract with interferon alpha-2 alpha.  |  Relakis, K., et al. 1996. Oncol Rep. 3: 951-5. PMID: 21594489
5. IFNA2 p.Ala120Thr impairs the inhibitory activity of Interferon-α2 against the hepatitis B virus through altering its binding to the receptor.  |  Chen, C., et al. 2017. Antiviral Res. 147: 11-18. PMID: 28958921
6. microRNA-499-3p inhibits proliferation and promotes apoptosis of retinal cells in diabetic retinopathy through activation of the TLR4 signaling pathway by targeting IFNA2.  |  Liu, X., et al. 2020. Gene. 741: 144539. PMID: 32160960
7. Intranasal interferon-alpha 2 for prevention of natural rhinovirus colds.  |  Farr, BM., et al. 1984. Antimicrob Agents Chemother. 26: 31-4. PMID: 6089652
8. Immunomodulation by recombinant interferon-alpha 2 in a phase I trial in patients with lymphoproliferative malignancies.  |  Ozer, H., et al. 1983. J Biol Response Mod. 2: 499-515. PMID: 6607323
9. High-level expression of an interferon alpha 2 gene cloned in phage M13mp7 and subsequent purification with a monoclonal antibody.  |  Slocombe, P., et al. 1982. Proc Natl Acad Sci U S A. 79: 5455-9. PMID: 6752948
10. Analysis of interferon-alpha 2 sequences in human genomic DNA.  |  Gewert, D., et al. 1993. J Interferon Res. 13: 227-31. PMID: 8366289

The preferred IFN-α2 antibody is IFN-α2 Antibody (MT4/E4): sc-53342.