IFN-α/βRβ Antibody (F-7): sc-137209
- IFN-α/βRβ Antibody (F-7) is a mouse monoclonal IgG2a κ IFN-α/βRβ antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 22-236 mapping near the N-terminus of IFN-α/βRβ of mouse origin
- IFN- alpha / beta R beta Antibody (F-7) is recommended for detection of IFN-α/βRβ of mouse origin by WB, IP, IF, IHC(P) and ELISA
- Anti-IFN- alpha / beta R beta Antibody (F-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IFN-α/βRβ Antibody (F-7) for WB and IHC(P) applications. These reagents are now offered in bundles with IFN-α/βRβ Antibody (F-7) (see ordering information below).
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IFN-α/βRβ Antibody (F-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects IFN-α/βRβ of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-IFN-α/βRβ antibody (F-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IFN-α/βRβ plays a crucial role in immune response as part of the receptor complex that mediates type I interferon effects, which are vital for establishing an antiviral state in cells. This receptor complex is essential for binding and signaling of IFN-α and IFN-β, which are produced in response to viral infections and double-stranded RNA. IFN-α/βRβ binding and response to these interferons is critical for initiating appropriate immune response, thereby enhancing host defense against viral pathogens. IFN-α/βRβ is expressed as two alternatively spliced transcripts, IFN-α/βRα and IFN-α/βRβ, both integral to signal transduction and ligand binding, further underscoring IFN-α/βRβ importance in immune regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IFN-α/βRβ Antibody (F-7) References:
- Novel IFN-alpha receptor promoter polymorphisms. | Muldoon, J., et al. 2001. Genes Immun. 2: 159-60. PMID: 11426326
- Expression of the IFN alpha receptor in hairy cell leukaemia. | Platanias, LC., et al. 1992. Br J Haematol. 82: 541-6. PMID: 1486034
- A conserved IFN-alpha receptor tyrosine motif directs the biological response to type I IFNs. | Zhao, W., et al. 2008. J Immunol. 180: 5483-9. PMID: 18390731
- Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha. | Claudinon, J., et al. 2009. J Biol Chem. 284: 24328-40. PMID: 19561067
- Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1. | Datta, S., et al. 2011. Virol J. 8: 351. PMID: 21756311
- IFN-Alpha receptor-1 upregulation in PBMC from HCV naïve patients carrying cc genotype. possible role of IFN-lambda. | Lalle, E., et al. 2014. PLoS One. 9: e93434. PMID: 24691098
- Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling. | Holmes, DA., et al. 2015. J Exp Med. 212: 1081-93. PMID: 26077719
- Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker. | Órpez-Zafra, T., et al. 2017. Mult Scler. 23: 937-945. PMID: 27613121
- IFN-alpha receptor deficiency enhances host resistance to oral Salmonella enterica serovar Typhimurium infection during murine pregnancy. | Agbayani, G., et al. 2021. Am J Reprod Immunol. 86: e13454. PMID: 33991140
- STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK-STAT endosomal activation. | Zanin, N., et al. 2023. Nat Cell Biol. 25: 425-438. PMID: 36797476
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-α/βRβ Antibody (F-7) | sc-137209 | 200 µg/ml | $322.00 | |||
IFN-α/βRβ Antibody (F-7): m-IgG Fc BP-HRP Bundle | sc-528875 | 200 µg Ab; 10 µg BP | $361.00 | |||
IFN-α/βRβ Antibody (F-7): m-IgGκ BP-HRP Bundle | sc-521451 | 200 µg Ab, 40 µg BP | $361.00 | |||
IFN-α/βRβ Antibody (F-7) AC | sc-137209 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IFN-α/βRβ Antibody (F-7) HRP | sc-137209 HRP | 200 µg/ml | $322.00 | |||
IFN-α/βRβ Antibody (F-7) FITC | sc-137209 FITC | 200 µg/ml | $336.00 | |||
IFN-α/βRβ Antibody (F-7) PE | sc-137209 PE | 200 µg/ml | $349.00 | |||
IFN-α/βRβ Antibody (F-7) Alexa Fluor® 488 | sc-137209 AF488 | 200 µg/ml | $364.00 | |||
IFN-α/βRβ Antibody (F-7) Alexa Fluor® 546 | sc-137209 AF546 | 200 µg/ml | $364.00 | |||
IFN-α/βRβ Antibody (F-7) Alexa Fluor® 594 | sc-137209 AF594 | 200 µg/ml | $364.00 | |||
IFN-α/βRβ Antibody (F-7) Alexa Fluor® 647 | sc-137209 AF647 | 200 µg/ml | $364.00 | |||
IFN-α/βRβ Antibody (F-7) Alexa Fluor® 680 | sc-137209 AF680 | 200 µg/ml | $364.00 | |||
IFN-α/βRβ Antibody (F-7) Alexa Fluor® 790 | sc-137209 AF790 | 200 µg/ml | $364.00 |