ICAP-1 Antibody (B-2): sc-166217
- ICAP-1 Antibody (B-2) is a mouse monoclonal IgG1 κ ICAP-1 antibody provided at 200 µg/ml
- raised against amino acids 1-200 representing full length ICAP-1 of human origin
- ICAP-1 Antibody (B-2) is recommended for detection of ICAP-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ICAP-1 Antibody (B-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ICAP-1 Antibody (B-2) for WB applications. These reagents are now offered in bundles with ICAP-1 Antibody (B-2) (see ordering information below).
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ICAP-1 Antibody (B-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects ICAP-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ICAP-1 (B-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ICAP-1, also known as Integrin beta-1-binding protein 1, plays a crucial role in cell adhesion and signaling by interacting with the cytoplasmic domain of Integrin β1 (ITGB1). This interaction is vital for the recruitment of Integrin β1 to focal contacts during integrin-dependent cell adhesion, which is essential for processes such as cell migration, survival, proliferation, and differentiation. Proper functioning of ICAP-1 is important for maintaining tissue integrity and facilitating cellular responses to the extracellular matrix. ICAP-1 is primarily expressed in various tissues, including the intestine, colon, testis, ovary, thymus, spleen, and prostate, highlighting its significance in both normal physiology and potential pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ICAP-1 Antibody (B-2) References:
- Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation. | Zhang, J., et al. 2001. Hum Mol Genet. 10: 2953-60. PMID: 11741838
- Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. | Chang, DD., et al. 2002. J Biol Chem. 277: 8140-5. PMID: 11741908
- Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. | Calderwood, DA., et al. 2003. Proc Natl Acad Sci U S A. 100: 2272-7. PMID: 12606711
- An unappreciated role for RNA surveillance. | Hillman, RT., et al. 2004. Genome Biol. 5: R8. PMID: 14759258
- CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. | Zawistowski, JS., et al. 2005. Hum Mol Genet. 14: 2521-31. PMID: 16037064
- In vitro analysis of integrin expression during chondrogenic differentiation of mesenchymal stem cells and chondrocytes upon dedifferentiation in cell culture. | Goessler, UR., et al. 2006. Int J Mol Med. 17: 301-7. PMID: 16391830
- Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations. | Plummer, NW., et al. 2006. Mamm Genome. 17: 119-28. PMID: 16465592
- ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. | Chang, DD., et al. 1997. J Cell Biol. 138: 1149-57. PMID: 9281591
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICAP-1 Antibody (B-2) | sc-166217 | 200 µg/ml | $322.00 | |||
ICAP-1 Antibody (B-2): m-IgG Fc BP-HRP Bundle | sc-528922 | 200 µg Ab; 10 µg BP | $361.00 | |||
ICAP-1 Antibody (B-2): m-IgGκ BP-HRP Bundle | sc-521536 | 200 µg Ab, 40 µg BP | $361.00 | |||
ICAP-1 Antibody (B-2): m-IgG1 BP-HRP Bundle | sc-543213 | 200 µg Ab; 20 µg BP | $361.00 | |||
ICAP-1 Antibody (B-2) AC | sc-166217 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ICAP-1 Antibody (B-2) HRP | sc-166217 HRP | 200 µg/ml | $322.00 | |||
ICAP-1 Antibody (B-2) FITC | sc-166217 FITC | 200 µg/ml | $336.00 | |||
ICAP-1 Antibody (B-2) PE | sc-166217 PE | 200 µg/ml | $349.00 | |||
ICAP-1 Antibody (B-2) Alexa Fluor® 488 | sc-166217 AF488 | 200 µg/ml | $364.00 | |||
ICAP-1 Antibody (B-2) Alexa Fluor® 546 | sc-166217 AF546 | 200 µg/ml | $364.00 | |||
ICAP-1 Antibody (B-2) Alexa Fluor® 594 | sc-166217 AF594 | 200 µg/ml | $364.00 | |||
ICAP-1 Antibody (B-2) Alexa Fluor® 647 | sc-166217 AF647 | 200 µg/ml | $364.00 | |||
ICAP-1 Antibody (B-2) Alexa Fluor® 680 | sc-166217 AF680 | 200 µg/ml | $364.00 | |||
ICAP-1 Antibody (B-2) Alexa Fluor® 790 | sc-166217 AF790 | 200 µg/ml | $364.00 |