Molecular structure of IBC 293, CAS Number: 306935-41-1
IBC 293 (CAS 306935-41-1)
Application:
IBC 293 is a selective HM74/GPR109b receptor agonist
CAS Number:
306935-41-1
Molecular Weight:
205.2
Molecular Formula:
C10H11N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IBC 293 is a cell permeable Niacin triazolo derivative that is a selective agonist towards the human orphan G-protein-coupled receptor GPR109b/HM74. In addition, IBC 293 inhibits forskolin (sc-3562) and isoproterenol (sc-202188) in GPR109b-expressing CHO cells and human adipocytes. The inhibition of forskolin and isoproterenol also causes a reduction in cAMP levels in both cell lines. It has been reported that GPR 109b occurs as homodimers and heterodimers in which the extent of homo-dimerization and hetero-dimerization does not depend on ligand binding.
IBC 293 (CAS 306935-41-1) References
- Evidence for constitutive dimerization of niacin receptor subtypes. | Mandrika, I., et al. 2010. Biochem Biophys Res Commun. 395: 281-7. PMID: 20380810
- Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways. | Zhou, Q., et al. 2012. Br J Pharmacol. 166: 1756-73. PMID: 22289163
- Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches. | George, AJ., et al. 2013. FEBS J. 280: 5258-68. PMID: 23992425
- Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism. | Stäubert, C., et al. 2015. Oncotarget. 6: 19706-20. PMID: 25839160
- Hydroxycarboxylic acid receptor 3 and GPR84 - Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells. | Peters, A., et al. 2022. Pharmacol Res. 176: 106047. PMID: 34968686
Activator of:
HM74.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IBC 293, 25 mg | sc-203079 | 25 mg | $200.00 |