HBED CAS: 35369-53-0
MF: C20H24N2O6•HCl
MW: 424.89
An iron chelator and hydroxyl radical inhibitor.

HBED (CAS 35369-53-0)

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Sinonimo: N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid monohydrochloride
Applicazione: An iron chelator and hydroxyl radical inhibitor
Numero CAS: 35369-53-0
Peso molecolare: 424.89
Formula molecolare: C20H24N2O6•HCl
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HBED, or hydroxybenzyl ethylenediamine, is a potent iron chelating compound. Through complexation with ferric ions, HBED is described to facilitate Fe(II) oxidation and to block O2(.-)-induced reduction of Fe(III), consequently blocking the Fe-mediated formation of hydroxyl radicals. HBED has been utilized as a tool for studying the involvement of hydroxyl radicals in cellular processes. HBED has specifically demonstrated to inhibit H2O2-induced apoptosis in neutrophils, suggesting participation of hydroxyl radicals in the mediation of neutrophilic apoptosis.


Referenze

1. Hershko, C., et al. 1984. J. Lab. Clin. Med. 103: 337-346. PMID: 6699459
2. Rollet-Labelle, E., et al. 1998. Free Radic. Biol. Med. 24: 563-572. PMID: 9559868
3. Gozin, A., et al. 1998. Free Radic. Biol. Med. 25: 1021-1032. PMID: 9870555
4. Faller, B., et al. 2000. J. Med. Chem. 43: 1467-1475. PMID: 10780902
5. Samuni, A.M., et al. 2001. Free Radic. Biol. Med. 30: 170-177. PMID: 11163534

Stato fisico :
Solid
Solubilità :
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml) at 40° C, and water (4 mg/ml) at 50° C (with vigorous agitation approximately 15 minutes).
CONSERVAZIONE :
Store at room temperature
Indice di rifrazione :
n20D 1.65
Valori pK :
pKa: 1.77, 8.03
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
66848913
Numero MDL :
MFCD04113603
SMILES :
C1=CC=C(C(=C1)CN(CCN(CC2=CC=CC=C2O)CC(=O)O)CC(=O)O)O.Cl

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