Date published: 2026-6-4

1-800-457-3801

SCBT Portrait Logo
Seach Input

H2-Kk,p,q,r,s Antibody (NYRmH-2K): sc-73293

2.0(1)
Write a reviewAsk a question

Datasheets
  • H2-Kk,p,q,r,s Antibody (NYRmH-2K) is a mouse monoclonal IgG2b provided at 100 µg/ml
  • raised against purified lymph nodes of C57BL/6 mouse origin
  • recommended for detection of MHC class I haplotypes k,p,q,r and s of mouse origin by FCM; non cross-reactive with H2-Kd
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for H2-Kk,p,q,r,s Antibody (NYRmH-2K). This work is in progress.
    Gene Editing Promo Banner

    QUICK LINKS

    SEE ALSO...

    H2-Kk,p,q,r,s Antibody (NYRmH-2K) is a mouse monoclonal IgG2b antibody that detects H2-Kk,p,q,r,s in mouse samples through flow cytometry (FCM). H2-Kk,p,q,r,s is a critical component of the major histocompatibility complex (MHC) class I molecules, which play a vital role in the immune response by presenting foreign peptides to cytotoxic T lymphocytes (CTLs). H2-Kk,p,q,r,s exists as a heterodimer, consisting of an alpha chain and a non-covalently associated beta-2-microglobulin chain, and is essential for the recognition of infected or malignant cells by the immune system. The presence of various haplotypes, including Kk, Kp, Kq, Kr, and Ks, allows for a diverse immune response, enabling the body to effectively identify and eliminate a wide range of pathogens. The ability of H2-Kk,p,q,r,s to present antigens is crucial for the activation of CTLs, which are key players in the adaptive immune response, making H2-Kk,p,q,r,s indispensable for maintaining immune surveillance and homeostasis. Anti-H2-Kk,p,q,r,s antibody (NYRmH-2K) is an invaluable tool for researchers studying immune responses in mouse models, providing insights into the mechanisms of antigen presentation and T cell activation.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    H2-Kk,p,q,r,s Antibody (NYRmH-2K) References:

    1. Jun oncoproteins do not function as primary transcription factors for the mouse major histocompatibility complex class I H-2 genes in fibroblasts.  |  Hatina, J. and Reischig, J. 2003. Eur J Immunogenet. 30: 253-7. PMID: 12919286
    2. Major histocompatibility complex antigens in v-Ki-ras transformed cells: the different antigens are expressed and induced by interferons independently of one another and of the anti-viral state.  |  Morris, AG. 1990. Immunology. 71: 224-9. PMID: 1699881
    3. Reduced tumorigenicity of murine tumor cells secreting gamma-interferon is due to nonspecific host responses and is unrelated to class I major histocompatibility complex expression.  |  Esumi, N., et al. 1991. Cancer Res. 51: 1185-9. PMID: 1900037
    4. Antigen-specific recognition is critical for the function of regulatory CD8(+)CD28(-) T cells.  |  Renner, P., et al. 2010. Transpl Immunol. 22: 144-9. PMID: 19840851
    5. MicroRNAs Involved in Acute Rejection and Tolerance in Murine Cardiac Allografts.  |  Fujino, M., et al. 2016. Exp Clin Transplant. 14: 424-30. PMID: 27227980
    6. A minigene DNA vaccine encoding peptide epitopes derived from Galectin-1 has protective antitumoral effects in a model of neuroblastoma.  |  Liebscher, L., et al. 2021. Cancer Lett. 509: 105-114. PMID: 33848518
    7. Purification of the H-2Kk molecule of the murine major histocompatibility complex.  |  Herrmann, SH. and Mescher, MF. 1979. J Biol Chem. 254: 8713-6. PMID: 479148
    8. In vivo phenotypic characteristics of AKR T-cell lymphomas with different leukemic potential: possible role of alpha 4 beta 7 integrin in the progression towards the leukemic phenotype.  |  Dolcetti, R., et al. 1994. Int J Cancer. 56: 560-7. PMID: 8112892
    9. An acidic modification of the cytoplasmic domain contributes to the charge heterogeneity of the MHC class I antigens.  |  Balomenos, D. and Poretz, RD. 1998. Immunogenetics. 47: 381-9. PMID: 9510556
    10. Glycan-regulated antigen processing of a protein in the endoplasmic reticulum can uncover cryptic cytotoxic T cell epitopes.  |  Wood, P. and Elliott, T. 1998. J Exp Med. 188: 773-8. PMID: 9705959

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    H2-Kk,p,q,r,s Antibody (NYRmH-2K)

    sc-73293
    100 µg/ml
    $322.00