Guvacine hydrochloride CAS: 6027-91-4
MF: C6H9NO2•HCl
MW: 163.60
Inhibits GABA uptake.

Guvacine hydrochloride (CAS 6027-91-4)

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Applicazione: Guvacine hydrochloride is inhibits GABA uptake
Numero CAS: 6027-91-4
Purezza: ≥97%
Peso molecolare: 163.60
Formula molecolare: C6H9NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Guvacine hydrochloride inhibits GABA uptake (IC50 values are 14, 58, 119 and 1870 μM for hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1 respectively). GABA transporters belong to the solute carrier family 6 (SLC6) and are sodium- and chlorde-dependent members that mediate the rapid removal of GABA.


Referenze

Rovira, et al., Somatic and dendritic and dendritic actions of gamma-aminobutyric acid agonist and uptake blockers in the hippocampus in vivo. Neuroscience 12, 543, (1984) Krause, et al., Dose-conductance relationships for GABA agonists and the effect of uptake inhibitors in crayfish stretch receptor neurons. Brain Res. 225, 319, (1981) Johnston, et al., Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake. Nature 258, 6228, (1975)

Stato fisico :
Solid
Solubilità :
H2O: soluble: ethanol: slightly soluble
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
306-309° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1CNCC(=C1)C(=O)O.Cl

Download SDS (MSDS)

CERTIFICATO DI ANALISI

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