Molecular structure of GSK 2334470, CAS Number: 1227911-45-6
GSK 2334470 (CAS 1227911-45-6)
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Alternate Names:
(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide
Application:
GSK 2334470 is a potent and selective PDK1 inhibitor that subsequently induces apoptotic cell death
CAS Number:
1227911-45-6
Purity:
≥99%
Molecular Weight:
462.59
Molecular Formula:
C25H34N8O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GSK 2334470 is a potent and highly selective PKB Kinase inhibitor (IC50 ~ 10nM). This compound exhibits no effect on a variety of other kinases, including Aurora, ROCK, p38 MAPK and PI3K. This compound also suppresses T-loop phosphorylation and subsequent activation of PKB Kinase substrates S6K1, SGK, and RSK in HEK 293, U87, and mouse embryonic fibroblast cell lines. The selectivity of GSK 2334470 allows for determination of the role of PKB Kinase in various cell lines, including cancerous cell lines. This compound also has a limited inhibitory effect on Akt activation.
GSK 2334470 (CAS 1227911-45-6) References
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- Deletion of PDK1 causes cardiac sodium current reduction in mice. | Han, Z., et al. 2015. PLoS One. 10: e0122436. PMID: 25781322
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- Hippocalcin Promotes Neuronal Differentiation and Inhibits Astrocytic Differentiation in Neural Stem Cells. | Park, SY., et al. 2017. Stem Cell Reports. 8: 95-111. PMID: 28017654
- Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells. | Wiredja, DD., et al. 2018. Retrovirology. 15: 44. PMID: 29970186
- Correction to: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens. | Pandey, SP., et al. 2019. Mucosal Immunol. 12: 1065. PMID: 31182816
- Importance of phosphorylation/dephosphorylation cycles on lipid-dependent modulation of membrane protein topology by posttranslational phosphorylation. | Vitrac, H., et al. 2019. J Biol Chem. 294: 18853-18862. PMID: 31645436
- FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM. | Watanabe, D., et al. 2019. Cancers (Basel). 11: PMID: 31756944
- Transcriptional regulation of the IL-13Rα2 gene in human lung fibroblasts. | Penke, LR., et al. 2020. Sci Rep. 10: 1083. PMID: 31974428
- Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions. | Yan, J., et al. 2020. J Immunol. 205: 1024-1038. PMID: 32690658
- In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway. | Ocklenburg, T., et al. 2021. Sci Rep. 11: 7199. PMID: 33785835
- Phosphoinositol 3-kinase-driven NET formation involves different isoforms and signaling partners depending on the stimulus. | de Carvalho Oliveira, V., et al. 2023. Front Immunol. 14: 1042686. PMID: 36761736
- PDK1 inhibition reduces autophagy and cell senescence through the PI3K/AKT signalling pathway in a cigarette smoke mouse emphysema model. | Zhang, P., et al. 2023. Exp Ther Med. 25: 223. PMID: 37123206
Inhibitor of:
ACSVL5, Bpifa6, C030048H21Rik, C14orf182, Centaurin γ3, DSC54, EG627853, FHL1, FIZ, HoxB8, KIDINS220, Olfr805, Olfr815, pan 14-3-3, PDK1, PIPK I β, PKB Kinase, Rsk-2, Ser/Thr Protein Kinase, Sgk494, TBC1D14, TMEM55B, TRPC3, Ypk2, Zfp13, and ZNF514.Activator of:
C17orf63, Eph A8, FGF-19, FGF-8F, ISG20, LATS1, PLEKHA4, Rictor, SDF-1, SH3TC1, and ZIP-kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK 2334470, 10 mg | sc-364501 | 10 mg | $199.00 | |||
GSK 2334470, 50 mg | sc-364501A | 50 mg | $1165.00 |