Grancalcin Antibody (C-10): sc-393984
- Grancalcin Antibody (C-10) is a mouse monoclonal IgG3 (lambda light chain) provided at 200 µg/ml
- specific for an epitope mapping between amino acids 189-214 at the C-terminus of Grancalcin of human origin
- recommended for detection of Grancalcin of human origin by WB, IP, IF and ELISA
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for Grancalcin Antibody (C-10) for WB applications. This reagent is now offered in a bundle with Grancalcin Antibody (C-10) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Grancalcin Antibody (C-10) is a mouse monoclonal IgG3 antibody that detects Grancalcin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Grancalcin is a calcium-binding protein predominantly found in human neutrophils and plays a crucial role in the immune response. Grancalcin belongs to the penta EF-hand (PEF) subfamily of EF-hand proteins, which includes calpain, sorcin, peflin, and ALG-2. Grancalcin′s structure is characterized by its ability to form a homodimer through the association of unpaired EF5 hands, which is essential for function. Upon binding calcium, Grancalcin undergoes significant conformational changes that expose hydrophobic amino acid residues, allowing interaction with hydrophobic surfaces and potentially influencing cellular processes. Notably, Grancalcin interacts with L-plastin, a protein known for actin bundling activity, suggesting involvement in regulating neutrophil adhesion, a critical aspect of the immune response. Anti-Grancalcin antibody (C-10) is particularly valuable for researchers studying the dynamics of neutrophil function and the underlying mechanisms of immune regulation. Grancalcin is primarily associated with cells originating from the bone marrow, with highest expression levels found in neutrophils and monocytes, while only trace amounts are detected in lymphocytes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Grancalcin Antibody (C-10) | sc-393984 | 200 µg/ml | $322.00 | |||
Grancalcin Antibody (C-10): m-IgGλ BP-HRP Bundle | sc-524167 | 200 µg Ab, 40 µg BP | $361.00 | |||
Grancalcin (C-10) Neutralizing Peptide | sc-393984 P | 100 µg/0.5 ml | $69.00 |