Gossypol CAS: 303-45-7
MF: C30H30O8
MW: 518.56
Gossypol is an inhibitor of PKC, Bcl-2, 5-LO, and 12-LO.

Gossypol (CAS 303-45-7)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 100ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Gossypol is rated 5.0 out of 5 by 1.
loading
5
1
4
0
3
0
2
0
1
0
Nomi alternativi: Pogosin; AT101; 2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)
Applicazione: Gossypol is an inhibitor of PKC, Bcl-2, 5-LO, and 12-LO
Numero CAS: 303-45-7
Purezza: ≥90%
Peso molecolare: 518.56
Formula molecolare: C30H30O8
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
loading

Gossypol is a male antifertility agent with antispermatogenic activity and has been shown to contain antitumor, anitviral, and antioxidant properties. Gossypol is a reversible inhibitor of PP2B (protein phosphatase 2B), mitotic kinesin Eg5, and PKC (protein kinase C). Gossypol also potentially inhibits PAF-R, Bcl-2, 5-LO (5-lipoxygenase), 12-LO, and leukotriene-induced guinea pig parenchyma contractions. Gossypol is an inhibitor of Bcl-xl.


Referenze

1. Qian, S.Z. and Wang, Z.G. 1984. Annu. Rev. Pharmacol. Toxicol. 24: 329-360. PMID: 6375548

2. Hamasaki, Y.and Tai, H.H. 1985. Biochim. Biophys. Acta. 834: 37-41. PMID: 3919771

3. Medrano, F.J. and Andreu, J.M. 1986. Eur. J. Biochem. 158: 63-69. PMID: 3732269

4. Shidaifat, F., et al. 1997. Anticancer Res. 17: 1003-1009. PMID: 9137441

5. Wang, X., et al. 2000. Life Sci. 67: 2663-2671. PMID: 11105982

6. Jiang, J., et al. 2004. Anticancer Res. 24: 91-100. PMID: 15015581

7. Dodou, K., et al. 2005. Expert Opin Investig Drugs. 14: 1419-1434. PMID: 16255680

Utilizzo :
Gossypol is soluble in ethanol with gentle warming and DMSO.
Stato fisico :
Solid
Derivato da :
Gossypium genus, Malvaceae
Solubilità :
Soluble in 100%ethanol (25 mg/ml), DMF (25 mg/ml), acetone, DMSO (25 mM), methanol (2 mg/ml), ether, chloroform, sodium carbonate, and dilute aqueous solutions of ammonia . Insoluble in water.
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
199° C
Punto di ebollizione :
~707.9° C at 760 mmHg (Predicted)
Densità :
~1.40 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.74
IC50 :
mitotic kinesin Eg5: IC50 = 10.8 µM; RBL-1, 5-lipoxygenase: IC50 = 0.3 µM; 12-lipoxygenase: IC50 = 0.7 µM; PC-3 (Prostate carcinoma cells): EC5050 = 17.8 µM (Homo sapiens); PC-3 (Prostate carcinoma cells): EC5050 = 3.3 µM (Homo sapiens); Transitional endoplasmic reticulum ATPase: IC50 = 5.39 µM (Homo sapiens); Induced myeloid leukemia cell differentiation protein Mcl-1: IC50 = 1.36 µM (Homo sapiens); Estrogen receptor beta: IC50 >50 µM (Homo sapiens); Apoptosis regulator Bcl-2: IC50 = 0.5 µM (Homo sapiens); HCT-116 (Colon carcinoma cells): IC50 = 3.3 µM (Homo sapiens); Malate dehydrogenase mitochondrialMalate dehydrogenase mitochondrial: IC50 = 2.8 µM (Sus scrofa); MDA-MB-231 (Breast adenocarcinoma cells): IC50 = 1.9 µM (Homo sapiens); Lactate dehydrogenase: IC50 = 2.64 µM (Plasmodium falciparum); Malate dehydrogenase: IC50 = 2.03 µM (Plasmodium falciparum)
Ki Data :
Induced myeloid leukemia cell differentiation protein Mcl-1: Ki= 0.18 µM (Homo sapiens); Apoptosis regulator Bcl-X: Ki= 0.48 µM (Homo sapiens); Apoptosis regulator Bcl-2: Ki= 0.32 µM (Homo sapiens); Aldose reductase: Ki= 0.5 µM (Homo sapiens); Apoptosis regulator Bcl-2: Ki= 0.17 µM (Homo sapiens); Apoptosis regulator Bcl-W: Ki= 17.7 µM (Homo sapiens)
Valori pK :
pKa: 7.15
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
DU3100000
PubChem CID :
Indice Merck :
14: 4528
Numero MDL :
MFCD00017352
SMILES :
CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C

Download SDS (MSDS)

CERTIFICATO DI ANALISI

Adobe Acrobat Reader necessario per una visualizzazione affidabile,
stampa e commenta sui documenti PDF

Gossypol (CAS 303-45-7)  Citazioni prodotti

Vedi quanti altri hanno usato Gossypol (CAS 303-45-7). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 11 totali

PMID: # 30678458  Lim, W.|Ham, J.|Park, S.|Bae, H.|You, S.|Song, G.| et al. 2019. J. Agric. Food Chem.

PMID: # 28252652  Ferdek, PE. et al. 2017. Cell Death Dis. 8: e2640.

PMID: # 25048245  Sundaram, B. et al. 2014. Biotechnol. Lett. 36: 2473-80.

PMID: # 11105982  Wang, X. et al. 2000. Life Sci. 67: 2663-2671.

PMID: # 6375548  Qian, SZ. et al. 1984. Annu. Rev. Pharmacol. Toxicol. 24: 329-360.

PMID: # 15015581  Jiang, J. et al. 2004 Jan-Feb. Anticancer Res. 24: 91-100.

PMID: # 25518940  Mol Biol Cell. 805-20.

PMID: # 9137441  Shidaifat, F. et al. 1997 Mar-Apr. Anticancer Res. 17: 1003-1009.

PMID: # 31173249  Oncol. Rep. 42: 467-478.

PMID: # 23838624  Goncharova, I. et al. Biophys. Chem. 180-181: 55-65.

Ciatazioni 1 a10 di 11 totali
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 105ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 46ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;