Molecular structure of Gly-Pro, CAS Number: 704-15-4
Gly-Pro (CAS 704-15-4)
Alternate Names:
Glycylproline
Application:
Gly-Pro is a chemical found to exhibit anti-ischemic effects on the metabolism of neuroactive amino acids
CAS Number:
704-15-4
Purity:
≥95%
Molecular Weight:
172.18
Molecular Formula:
C7H12N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Glycyl-L-proline (Gly-Pro) is a dipeptide consisting of the amino acids glycine and L-proline, with the latter being an essential amino acid. It has demonstrated the ability to reduce oxidative stress in septic rats and inhibit the growth of Candida albicans in mice. Moreover, Gly-Pro exhibits anti-ischemic effects on neuroactive amino acid metabolism and energy turnover in the neocortex of rats following experimental brain ischemia.
Gly-Pro (CAS 704-15-4) References
- Enhanced tumor cell selectivity of adriamycin-monoclonal antibody conjugate via a poly(ethylene glycol)-based cleavable linker. | Suzawa, T., et al. 2002. J Control Release. 79: 229-42. PMID: 11853934
- Characterization of prolidase activity in erythrocytes from a patient with prolidase deficiency: comparison with prolidase I and II purified from normal human erythrocytes. | Liu, G., et al. 2005. Clin Biochem. 38: 625-31. PMID: 16009141
- Multiple carriers for dipeptide transport: carrier-mediated transport of glycyl-L-proline in renal BBMV. | Skopicki, HA., et al. 1991. Am J Physiol. 261: F670-8. PMID: 1928378
- Antihypertensive effect of enzymatic hydrolysate of collagen and Gly-Pro in spontaneously hypertensive rats. | Ichimura, T., et al. 2009. Biosci Biotechnol Biochem. 73: 2317-9. PMID: 19809172
- [Reactivity of the central nervous system influences the sensitivity of secretory cells of the stomach to carbacholine and glycyl-proline (Gly-Pro)]. | Tomova, TA., et al. 2015. Eksp Klin Farmakol. 78: 13-6. PMID: 26036005
- Potential impact of sitagliptin on collagen-derived dipeptides in diabetic osteoporosis. | Baerts, L., et al. 2015. Pharmacol Res. 100: 336-40. PMID: 26342756
- Gly-Pro protects normal human dermal fibroblasts from UVA-induced damages via MAPK-NF-κB signaling pathway. | Liu, S., et al. 2022. J Photochem Photobiol B. 237: 112601. PMID: 36434834
- Rebound increase in circulating dipeptidyl peptidase 4 (DPP4) enzyme activity after acute COVID-19. | Firneisz, G. 2023. Proc Natl Acad Sci U S A. 120: e2220067120. PMID: 36623196
- Competition between carnosine and other peptides for transport by hamster jejunum in vitro. | Addison, JM., et al. 1974. Clin Sci Mol Med. 46: 707-14. PMID: 4851119
- Substrate specificity of manganese-activated prolidase in control and prolidase-deficient cultured skin fibroblasts. | Butterworth, J. and Priestman, D. 1984. J Inherit Metab Dis. 7: 32-4. PMID: 6429439
- New chromogenic substrates for X-prolyl dipeptidyl-aminopeptidase. | Nagatsu, T., et al. 1976. Anal Biochem. 74: 466-76. PMID: 962103
- Oxidation Of Di-Peptides With Mn(III): Synthesis, Characterization And Mechanistic Study | Kumara, M. N., Gowda, D., Gowda, C., & Rangappa, K. S. 2001. Reaction Kinetics and Catalysis Letters. 72: 331-342.
- Gly-Pro and Adaptive Reactions in Multicomponent Stress | Tomova, T. A., Zamoshchina, T. A., Svetlik, M. V., Sedokova, M. L., Gostyukhina, A. A., & Fatyushina, A. M. 2020. Neuroscience and Behavioral Physiology. 50: 1083-1089.
Activator of:
PEPT1, and PEPT2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gly-Pro, 10 g | sc-255188 | 10 g | $443.00 |