Flumazenil (Ro 15-1788) CAS: 78755-81-4
MF: C15H14FN3O3
MW: 303.29
A benzodiazepine antagonist.

Flumazenil (Ro 15-1788) (CAS 78755-81-4)

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Nomi alternativi: Anexate; Romazicon; Lanexat
Applicazione: Flumazenil (Ro 15-1788) is a benzodiazepine antagonist
Numero CAS: 78755-81-4
Purezza: ≥98%
Peso molecolare: 303.29
Formula molecolare: C15H14FN3O3
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Flumazenil is an antagonist to benzodiazepine allosteric binding on the GABAA receptor. Administration of Flumazenil has been shown to reverse many of the physiological effects associated with benzodiazepines and their modification of the GABAA system.


Referenze

1. File, S.E., et al. 1986. Psychopharmacology. 89: 113-117. PMID: 3090585
2. Mereu, G., et al. 1990. Eur. J. Pharmacol. 179: 339-345. PMID: 1973107
3. Bertz, R.J., et al. 1995. Neuropharmacology. 34: 1169-1175. PMID: 8532187

Stato fisico :
Solid
Solubilità :
Soluble in ethanol (5 mg/ml warm), DMSO (25 mg/ml warm), methanol, and chloroform. Partly miscible in water.
CONSERVAZIONE :
Store at room temperature
Punto di scioglimento :
~205.38° C (Predicted)
Punto di ebollizione :
528.0° C at 760 mmHg (Predicted)
Densità :
~1.40 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.63
IC50 :
GABA receptor alpha-1 subunit: IC50 = 0.5 nM (bovine); GABA receptor alpha-2 subunit: IC50 = 0.5 nM (bovine); GABA receptor alpha-3 subunit: IC50 = 0.5 nM (bovine); GABA receptor alpha-4 subunit: IC50 = 0.5 nM (bovine); GABA receptor beta-1 subunit: IC50 = 0.5 nM (bovine); GABA receptor gamma-2 subunit: IC50 = 0.5 nM (bovine)
Ki Data :
GABA receptor alpha-2 subunit: Ki= 0.09 nM (bovine); GABA receptor alpha-3 subunit: Ki= 0.09 nM (bovine); GABA receptor alpha-4 subunit: Ki= 0.09 nM (bovine); GABA receptor beta-1 subunit: Ki= 0.09 nM (bovine); GABA receptor gamma-2 subunit: Ki= 0.09 nM (bovine)
Valori pK :
pKa: 6.2
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
2
RTECS :
NI2922170
PubChem CID :
Indice Merck :
14: 4135
Numero MDL :
MFCD00242764
Registro Beilstein :
4763661
SMILES :
CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C

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Flumazenil (Ro 15-1788) (CAS 78755-81-4)  Citazioni prodotti

Vedi quanti altri hanno usato Flumazenil (Ro 15-1788) (CAS 78755-81-4). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 10 totali

PMID: # 10784479  Le Mellédo, JM. et al. 2000. Am J Psychiatry. 157: 821-823.

PMID: # 9695999  Barbaro, G. et al. 1998. Hepatology. 28: 374-378.

PMID: # 9585710  Ströhle, A. et al. 1998. Am J Psychiatry. 155: 610-612.

PMID: # 8878099  Nave, R. et al. 1996. Neurosci. Lett. 214: 123-126.

PMID: # 8129118  Murphy, PJ. et al. 1994. Anaesthesia. 49: 105-110.

PMID: # 8267193  Ghoneim, MM. et al. 1993. Anesthesiology. 79: 1183-1192.

PMID: # 1547055  Fennelly, ME. et al. 1992. Br J Anaesth. 68: 303-305.

PMID: # 2904525  Grimm, G. et al. 1988. Lancet. 2: 1392-1394.

PMID: # 3036316  Nutt, DJ. et al. 1987. Brain Res. 413: 193-196.

PMID: # 6815546  File, SE. et al. 1982. Neuropharmacology. 21: 1033-1037.

Ciatazioni 1 a10 di 10 totali
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