Molecular structure of FIPI, CAS Number: 939055-18-2
FIPI (CAS 939055-18-2)
See product citations (2)
Alternate Names:
5-Fluoro-2-Indolyl des-Chlorohalopemide
Application:
FIPI is a cell-permeable, PLD1/2 inhibitor
CAS Number:
939055-18-2
Purity:
≥98%
Molecular Weight:
421.50
Molecular Formula:
C23H24FN5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FIPI is a chemical compound recognized for its role in the study of phospholipase D (PLD) enzymes. Due to FIPI′s ability to inhibit PLD activity, it has become a important for understanding the biological functions of PLD, which include membrane trafficking, cell signaling, and secretion. Some may utilize FIPI to investigate the mechanisms by which PLD contributes to these cellular processes, and its role in various cellular models. FIPI is in studies examining the regulation of PLD and its interactions with other proteins within cells. FIPI also enables the exploration of the broader implications of PLD activity in cellular dynamics and function, providing insights that can inform the study of various biological systems.
FIPI (CAS 939055-18-2) References
- 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. | Su, W., et al. 2009. Mol Pharmacol. 75: 437-46. PMID: 19064628
- Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. | Secor, JD., et al. 2011. Int J Toxicol. 30: 619-38. PMID: 21994240
- A novel role for phospholipase D as an endogenous negative regulator of platelet sensitivity. | Elvers, M., et al. 2012. Cell Signal. 24: 1743-52. PMID: 22579635
- Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report. | Stegner, D., et al. 2013. Arterioscler Thromb Vasc Biol. 33: 2212-7. PMID: 23868933
- Orexin A inhibits propofol-induced neurite retraction by a phospholipase D/protein kinase Cε-dependent mechanism in neurons. | Björnström, K., et al. 2014. PLoS One. 9: e97129. PMID: 24828410
- Two sites of action for PLD2 inhibitors: The enzyme catalytic center and an allosteric, phosphoinositide biding pocket. | Ganesan, R., et al. 2015. Biochim Biophys Acta. 1851: 261-72. PMID: 25532944
- PLD-Specific Small-Molecule Inhibitors Decrease Tumor-Associated Macrophages and Neutrophils Infiltration in Breast Tumors and Lung and Liver Metastases. | Henkels, KM., et al. 2016. PLoS One. 11: e0166553. PMID: 27851813
- Structural Insights for Drugs Developed for Phospholipase D Enzymes. | Stieglitz, KA. 2018. Curr Drug Discov Technol. 15: 81-93. PMID: 28814238
- CAPA periviscerokinin-mediated activation of MAPK/ERK signaling through Gq-PLC-PKC-dependent cascade and reciprocal ERK activation-dependent internalized kinetics of Bom-CAPA-PVK receptor 2. | Shen, Z., et al. 2018. Insect Biochem Mol Biol. 98: 1-15. PMID: 29730398
- Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-α Regulation and Myocardial Healing. | Klier, M., et al. 2018. Front Physiol. 9: 1698. PMID: 30555342
- Preparation and Evaluation of Liposomes Co-Loaded with Doxorubicin, Phospholipase D Inhibitor 5-Fluoro-2-Indolyl Deschlorohalopemide (FIPI) and D-Alpha Tocopheryl Acid Succinate (α-TOS) for Anti-Metastasis. | Song, M., et al. 2019. Nanoscale Res Lett. 14: 138. PMID: 31001703
- The phospholipase D inhibitor FIPI potently blocks EGF-induced calcium signaling in human breast cancer cells. | Stricker, HM., et al. 2021. Cell Commun Signal. 19: 43. PMID: 33832505
- Classic Phytochemical Antioxidant and Lipoxygenase Inhibitor, Nordihydroguaiaretic Acid, Activates Phospholipase D through Oxidant Signaling and Tyrosine Phosphorylation Leading to Cytotoxicity in Lung Vascular Endothelial Cells. | Parinandi, NL., et al. 2023. Cell Biochem Biophys.. PMID: 36820994
Inhibitor of:
PC-PLD1, and PC-PLD2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FIPI, 1 mg | sc-294594 | 1 mg | $60.00 | |||
FIPI, 5 mg | sc-294594A | 5 mg | $171.00 | |||
FIPI, 10 mg | sc-294594B | 10 mg | $306.00 | |||
FIPI, 25 mg | sc-294594C | 25 mg | $692.00 |