Enalaprilat CAS: 76420-72-9
MF: C18H24N2O5
MW: 348.39
An active metabolite of Enalapril.

Enalaprilat (CAS 76420-72-9)

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Nomi alternativi: Enalaprilic acid; Enalaprilatum
Applicazione: Enalaprilat is an active metabolite of Enalapril
Numero CAS: 76420-72-9
Purezza: ≥99%
Peso molecolare: 348.39
Formula molecolare: C18H24N2O5
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Enalaprilat is the active form of Enalapril (sc-205664). Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.


Referenze

1. Kelly, J.G. and O′Malley, K. 1990. Clin Pharmacokinet. 19: 177-196. PMID: 2203579
2. Lupi, R., et al. 2006. Eur. J. Endocrinol. 154: 355-361. PMID: 16452552
3. Wang, S.L., et al. 2010. Sichuan Da Xue Xue Bao Yi Xue Ban. 41: 1003-7, 1038. PMID: 21265103
4. Zhang, Y.H., et al. 2010. Sichuan Da Xue Xue Bao Yi Xue Ban. 41: 998-1002. PMID: 21265102
5. Yim, H.E., et al. 2011. Pediatr Res. [Epub ahead of print]. PMID: 21263376

Stato fisico :
Solid
Solubilità :
Slightly soluble in water
CONSERVAZIONE :
Store at -20° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
SMILES :
CC(C(=O)N1CCCC1C(=O)O)NC(CCC2=CC=CC=C2)C(=O)O

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Enalaprilat (CAS 76420-72-9)  Citazioni prodotti

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PMID: # 33986677  Medhora, M.|Phadnis, P.|Narayanan, J.|Gasperetti, T.|Zielonka, J.|Moulder, JE.|Fish, BL.|Szabo, A.| et al. 2021. Front Pharmacol. 12: 646076.

PMID: # 29102378  de Faria, HD.|Bueno, CT.|Krieger, JE.|Krieger, EM.|Pereira, AC.|Santos, PCJL.|Figueiredo, EC.| et al. 2017. J Chromatogr A. 1528: 41-52.

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