E2F1 Antibody (D-10): sc-137110

E2F-1 Antibody (D-10) is a mouse monoclonal IgG1 antibody designed to detect E2F-1, also known as RBAP-1 or RBBP-3, in human, mouse, and rat samples. E2F-1 monoclonal antibody (D-10) targets the amino acids 301-437 of human E2F-1, making it ideal for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). E2F-1 is a critical transcription factor that plays a fundamental role in regulating the cell cycle, particularly by controlling the transition from the G1 phase to the S phase, where DNA replication occurs. By activating genes necessary for DNA synthesis and cell proliferation, E2F-1 ensures proper cell division and growth. Additionally, E2F-1 interacts with the retinoblastoma protein (Rb), a key regulator that inhibits E2F-1 activity to prevent uncontrolled cell proliferation. This interaction is essential for maintaining cellular homeostasis and preventing tumorigenesis. Dysregulation of E2F-1, whether through mutations or aberrant interactions with viral oncoproteins, can lead to unchecked cell growth and is a common feature in various cancers. Understanding the function of E2F-1 is crucial for elucidating the mechanisms of cell cycle control and the development of therapeutic strategies targeting cancer cell proliferation. anti-E2F-1 antibody (D-10) provides researchers with a tool to study the intricate pathways involving E2F-1, its regulatory mechanisms, and its role in both normal cellular processes and disease states.

The preferred E2F1 antibody is E2F1 Antibody (KH95): sc-251.