Molecular structure of Desisobutyryl Ciclesonide, CAS Number: 161115-59-9
Desisobutyryl Ciclesonide (CAS 161115-59-9)
Application:
Desisobutyryl Ciclesonide is A novel corticosteroid
CAS Number:
161115-59-9
Molecular Weight:
470.60
Molecular Formula:
C28H38O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Desisobutyryl Ciclesonide is a novel corticosteroid. Desisobutyryl ciclesonide, an acyclic dicarboxylic acid derivative, demonstrates notable enzyme inhibition properties. Studies have shown its effectiveness as an inhibitor of various enzymes, including cyclooxygenase-2 (COX-2) and phospholipase A2 (PLA2). Furthermore, desisobutyryl ciclesonide has garnered attention for its potential to impede the proliferation of bacteria and fungi.
Desisobutyryl Ciclesonide (CAS 161115-59-9) References
- Formation of fatty acid conjugates of ciclesonide active metabolite in the rat lung after 4-week inhalation of ciclesonide. | Nave, R., et al. 2005. Pulm Pharmacol Ther. 18: 390-6. PMID: 16179214
- High lung deposition of 99mTc-labeled ciclesonide administered via HFA-MDI to patients with asthma. | Newman, S., et al. 2006. Respir Med. 100: 375-84. PMID: 16275052
- In vitro metabolism of ciclesonide in human nasal epithelial cells. | Sato, H., et al. 2007. Biopharm Drug Dispos. 28: 43-50. PMID: 17117454
- In vitro activation of the corticosteroid ciclesonide in animal nasal mucosal homogenates. | Sato, H., et al. 2007. Biopharm Drug Dispos. 28: 59-64. PMID: 17163410
- The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue. | Mutch, E., et al. 2007. Biochem Pharmacol. 73: 1657-64. PMID: 17331475
- Comparative in vitro metabolism of 14C-ciclesonide in hepatocytes from the mouse, rat, rabbit, dog, and human. | Gu, Z., et al. 2007. Am J Ther. 14: 280-90. PMID: 17515705
- Uptake and metabolism of ciclesonide and retention of desisobutyryl-ciclesonide for up to 24 hours in rabbit nasal mucosa. | Sato, H., et al. 2007. BMC Pharmacol. 7: 7. PMID: 17553148
- Ciclesonide for the treatment of asthma. | Dahl, R. 2006. Ther Clin Risk Manag. 2: 25-38. PMID: 18360579
- Allometric modeling of ciclesonide, a nonhalogenated glucocorticoid, and its active metabolite, desisobutyrylciclesonide, using animal-derived pharmacokinetic parameters. | Srinivas, NR., et al. 2013. Am J Ther. 20: 261-6. PMID: 19417590
- Ciclesonide, a hypotonic intranasal corticosteroid. | Neffen, H. and Wingertzahn, MA. 2010. Allergy Asthma Proc. 31 Suppl 1: S29-37. PMID: 20557684
- Metabolism of ciclesonide in the upper and lower airways: review of available data. | Nave, R. and McCracken, N. 2008. J Asthma Allergy. 1: 11-8. PMID: 21436981
- Ciclesonide modulates in vitro allergen-driven activation of blood mononuclear cells and allergen-specific T-cell blasts. | Silvestri, M., et al. 2012. Immunol Lett. 141: 190-6. PMID: 22015638
- An Ultrasensitive LC-APPI-MS/MS Method for Simultaneous Determination of Ciclesonide and Active Metabolite Desisobutyryl-Ciclesonide in Human Serum and Its Application to a Clinical Study. | Chen, YL., et al. 2020. J Appl Lab Med. 5: 41-53. PMID: 31662413
- LC-HRMS/MS study of the prodrug ciclesonide and its active metabolite desisobutyryl-ciclesonide in plasma after an inhalative administration to horses for doping control purposes. | Trevisiol, S., et al. 2022. Drug Test Anal. 14: 252-261. PMID: 34634175
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desisobutyryl Ciclesonide, 1 mg | sc-211257 | 1 mg | $374.00 |