Molecular structure of Deferiprone, CAS Number: 30652-11-0
Deferiprone (CAS 30652-11-0)
See product citations (5)
Alternate Names:
3-hydroxy-1,2-dimethylpyridin-4-one
Application:
Deferiprone is a chelator that removes transferrin and ferritin in vitro
CAS Number:
30652-11-0
Molecular Weight:
139.15
Molecular Formula:
C7H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Deferiprone, also called 1,2-dimethyl-3-hydroxypyrid-4-one, is a hydroxypyrid-4-one compound utilized as a specific chelator of iron in biological systems. Deferiprone has been described in studies investigating the excretion of iron in iron overloaded systems. It works by selectively binding to free iron and forming a complex. Deferiprone demonstrates a specificity for iron over copper, zinc, calcium and magnesium. One of the key benefits of deferiprone, compared to other iron chelators, is its ability to penetrate cell membranes effectively and chelate intracellular iron, which is particularly important for the protection of heart cells.
Deferiprone (CAS 30652-11-0) References
- Deferiprone-related arthropathy of the knee in a thalassemic patient: report of a case and review of the literature. | Vlachaki, E., et al. 2008. Clin Rheumatol. 27: 1459-61. PMID: 18663554
- Deferiprone for the treatment of transfusional iron overload in thalassemia. | Belmont, A. and Kwiatkowski, JL. 2017. Expert Rev Hematol. 10: 493-503. PMID: 28448199
- New orally active iron chelators. | Kontoghiorghes, GJ. 1985. Lancet. 1: 817. PMID: 2858689
- Deferiprone has anti-inflammatory properties and reduces fibroblast migration in vitro. | Ramezanpour, M., et al. 2019. Sci Rep. 9: 2378. PMID: 30787349
- Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition. | Tran, NT., et al. 2020. Platelets. 31: 505-512. PMID: 31366263
- Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology. | Rao, SS., et al. 2021. Neurotherapeutics. 18: 1081-1094. PMID: 33410108
- Metabolic activation of deferiprone mediated by CYP2A6. | Zheng, X., et al. 2021. Xenobiotica. 51: 1282-1291. PMID: 34006188
- Identifying a Deferiprone-Resveratrol Hybrid as an Effective Lipophilic Anti-Plasmodial Agent. | Maneekesorn, S., et al. 2021. Molecules. 26: PMID: 34279413
- New synthetic approach and iron chelating studies of 1-alkyl-2-methyl-3-hydroxypyrid-4-ones. | Kontoghiorghes, GJ., et al. 1987. Arzneimittelforschung. 37: 1099-102. PMID: 3435580
- Deferiprone has less benefits on gut microbiota and metabolites in high iron-diet induced iron overload thalassemic mice than in iron overload wild-type mice: A preclinical study. | Sriwichaiin, S., et al. 2022. Life Sci. 307: 120871. PMID: 35952729
- Deferiprone and Iron-Maltol: Forty Years since Their Discovery and Insights into Their Drug Design, Development, Clinical Use and Future Prospects. | Kontoghiorghes, GJ. 2023. Int J Mol Sci. 24: PMID: 36902402
- The study of iron mobilisation from transferrin using alpha-ketohydroxy heteroaromatic chelators. | Kontoghiorghes, GJ. 1986. Biochim Biophys Acta. 869: 141-6. PMID: 3942757
- Orally active alpha-ketohydroxy pyridine iron chelators intended for clinical use: in vivo studies in rabbits. | Kontoghiorghes, GJ. and Hoffbrand, AV. 1986. Br J Haematol. 62: 607-13. PMID: 3964556
Inhibitor of:
ALKBH4, ALKBH6, Anamorsin, CRTAP, CYBRD1, EG434726, EG434727, EG434729, ferritin, Hepcidin, ISCA2, IscU1, IscU2, JMJD2B, mito293Tndrial ferritin, NRAMP2, NUBP1, OAZIN, OCRL, OGFOD2, OTTMUSG00000016694, PBGD, pHyde, pyridoxal phosphatase, RGMc, SLC48A1, TETRAN, TFR2, Torsin3A, transferrin, and Yfh1.Activator of:
C20orf72, COQ4, DOHH, FAM96A, FLVCR, FLVCR2, Frataxin, HFE, ISCA1, JMJD7, MAN2B1, Mel13, Miner2, mitochondrial ferritin, Mitoferrin, SFXN4, and TRIM5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Deferiprone, 1 g | sc-211220 | 1 g | $124.00 | |||
Deferiprone, 5 g | sc-211220A | 5 g | $134.00 |