D-myo-Inositol-1,2,3,4-tetraphosphate, sodium salt D-myo-Inositol-1,2,3,4-tetraphosphate, sodium salt is a IP3 receptor agonist in CHO cells.

D-myo-Inositol-1,2,3,4-tetraphosphate, sodium salt

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Nomi alternativi: Ins(1,2,3,4)-P4 sodium salt
Applicazione: D-myo-Inositol-1,2,3,4-tetraphosphate, sodium salt is a IP3 receptor agonist in CHO cells
Purezza: >98%
Peso molecolare: 588.0
Formula molecolare: C6H12O18P44Na
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

D-myo-Inositol-1,2,3,4-tetraphosphate, sodium salt is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals.1,2,3 Ins(1,2,3,4)-P4 displays agonist activity at the Ins(1,4,5)-P3 receptor expressed in CHO cells where it induces Ca2+ mobilization with an ED50 value of 18.1 μM, making it nearly 180-fold less effective than Ins(1,4,5)-P3 in the same assay.


Referenze

1 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993). 2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992). 3 Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436 49-67 (1998). 4 Burford, N.T., Nahorski, S.R., Chung, S., et al. Binding and activity of the nine possible regioisomers of myo-inositol tetrakisphosphate at the inositol 1,4,5-trisphosphate receptor. Cell Calcium 21 301-310 (1997).

Aspetto :
Lyophilized powder
Stato fisico :
Solid
CONSERVAZIONE :
Store at -20° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
SMILES :
O[[email protected]@H]1[[email protected]@H](O)[[email protected]](OP([O-])(O)=O)[[email protected]@H](OP([O-])(O)=O)[[email protected]@H](OP([O-])([OH+])=O)[[email protected]]1OP([O-])(O)=O.[Na].[Na+].[Na+].[Na+]

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