Cytokeratin 8 Antibody (19): sc-130312
- Cytokeratin 8 Antibody (19) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against recombinant Cytokeratin 8 of human origin
- recommended for detection of Cytokeratin 8 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See Cytokeratin 8 (C51): sc-8020 for Cytokeratin 8 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for Cytokeratin 8 Antibody (19) for WB and IHC(P) applications. These reagents are now offered in bundles with Cytokeratin 8 Antibody (19) (see ordering information below).
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Cytokeratin 8 Antibody (19) is a mouse monoclonal IgG2b antibody that detects Cytokeratin 8 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Cytokeratin 8 is a vital component of the cytoskeletal structure in epithelial cells, playing a crucial role in maintaining cellular integrity and providing mechanical support. Cytokeratin 8 expression is particularly significant in simple epithelia, where anti-Cytokeratin 8 antibody (19) detects pairing with Cytokeratin 18, and serves as a marker for tissue differentiation. Abnormal expression of Cytokeratin 8 in squamous cell carcinomas derived from stratified epithelia raises questions about potential roles in tumorigenesis, as Cytokeratin 8 has been associated with poor prognostic outcomes in oral squamous cell carcinomas and other malignancies. Cytokeratin 8 presence in non-small-cell lung cancers further underscores relevance in cancer research, potentially serving as a target for therapeutic interventions. Additionally, extracellular epitopes of Cytokeratin 8 on tumor cells present promising opportunities for developing targeted therapies, making Cytokeratin 8 monoclonal antibody (19) an essential tool for researchers investigating epithelial cell biology and cancer pathology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 8 Antibody (19) | sc-130312 | 200 µg/ml | $322.00 | |||
Cytokeratin 8 Antibody (19): m-IgG Fc BP-HRP Bundle | sc-539810 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cytokeratin 8 Antibody (19): m-IgG2b BP-HRP Bundle | sc-549749 | 200 µg Ab; 10 µg BP | $361.00 |