Cypermethrin, solid CAS: 52315-07-8
MF: C22H19Cl2NO3
Cypermethrin, solid is a potent inhibitor of calcineurin.

Cypermethrin, solid (CAS 52315-07-8)

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Applicazione: Cypermethrin, solid is a potent inhibitor of calcineurin
Numero CAS: 52315-07-8
Purezza: ≥96%
Peso molecolare: 416.3
Formula molecolare: C22H19Cl2NO3
Informazioni supplementari: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Cypermethrin is a synthetic compound that affects the Na+ ion channels on nerve cell membranes. It is a potent PP2B (calcineurin) inhibitor (IC50~0.03 nM). It may also have varied effects on ion channels. Cypermethrin toxicology depends on the precise ratio of cis- and trans-species present in commercial mixtures - for example a mitxure of 80:20 cis-trans species shows different toxicology to a mixture of 40:60 cis-trans species. Pure isomers of Cypermethrin form a solid while a mixture of isomers of Cypermethrin form a semi-solid or liquid.


Referenze

1. Enan, E. and Matsumura, F. 1992. Biochem. Pharmacol. 43: 1777-1784. PMID: 1315545

2. Narahashi, T. 1992. Trends Pharmacol. Sci. 13: 236-241. PMID: 1321523

3. Wang, J.H. and Stelzer, A. 1994. Neuroreport. 5: 2377-2380. PMID: 7881062

4. Enz, A. and Pombo-Villar, E. 1997. Biochem. Pharmacol. 54: 321-323. PMID: 9271338

Stato fisico :
Solid
Solubilità :
Soluble in ethanol (25 mg/ml), and DMSO. Insoluble in water.
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
81-82° C
Punto di ebollizione :
200° C (dec.)
Densità :
0.78 g/mL
Indice di rifrazione :
n20D 1.62
IC50 :
Photobacterium phosphoreum: EC5050 = 5.36-8.50 mg/L
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
2
RTECS :
GZ1250000
PubChem CID :
Numero MDL :
MFCD00055328
Numero EC :
257-842-9
SMILES :
CC1(C)C(\\C=C(/Cl)Cl)C1C(=O)OC(C#N)C1=CC(OC2=CC=CC=C2)=CC=C1

Download SDS (MSDS)

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Cypermethrin, solid (CAS 52315-07-8)  Citazioni prodotti

Vedi quanti altri hanno usato Cypermethrin, solid (CAS 52315-07-8). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 10 totali

PMID: # 27121078  Kim, H. et al. 2016. Mol Brain. 9: 45.

PMID: # 17202132  Li, T. et al. 2007. J. Biol. Chem. 282: 6619-6628.

PMID: # 15073173  Yuan, Z. et al. 2004. J. Biol. Chem. 279: 26105-26114.

PMID: # 15322113  Melendez, J. et al. 2004. J. Biol. Chem. 279: 53516-53523.

PMID: # 12775717  Suo, Z. et al. 2003. J. Biol. Chem. 278: 31177-31183.

PMID: # 12654916  Ahn, J. et al. 2003. J. Biol. Chem. 278: 20480-20489.

PMID: # 12228222  Melendez, J. et al. 2002. J. Biol. Chem. 277: 45203-45210.

PMID: # 12386164  Ahn, J. et al. 2002. J. Biol. Chem. 277: 48418-48426.

PMID: # 11084033  Gliksman, NR. et al. 2001. J. Biol. Chem. 276: 5235-5239.

PMID: # 10913127  Mercado, A. et al. 2000. J. Biol. Chem. 275: 30326-30334.

Ciatazioni 1 a10 di 10 totali
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