Cucurbitacin I CAS: 2222-07-3
MF: C30H42O7
MW: 514.65
A Stat3 and JAK2 inhibitor and antiproliferative agent.

Cucurbitacin I (CAS 2222-07-3)

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Cucurbitacin I is rated 5.0 out of 5 by 1.
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Nomi alternativi: Elatericin B
Applicazione: Cucurbitacin I is a Stat3 and JAK2 inhibitor and antiproliferative agent
Numero CAS: 2222-07-3
Purezza: ≥95%
Peso molecolare: 514.65
Formula molecolare: C30H42O7
Informazioni supplementari: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Cucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells. These transcription factors have been known to mediate a wide variety of biological functions in the peripheral and central nervous systems. Their inhibition can result in the suppression of Stat3 DNA binding and Stat3-mediated gene transcription. Additionally this compound has been found to reduce in vitro clonogenicity of certain cancer cells. The anti-proliferation activity of this compound is also related to its downregulating activity against Stat3 target gene expression. Hyperactivation of the JAK2 (Janus-activated kinase 2) has been reported to be responsible for abnormal dendritic cell differentiation. The blocking of this kinase by Curcurbitacin I could potentially stop abnormal dendrite cell differentiation and promote differentiation of mature macrophages and dendritic cells. Cucurbitacin I, Cucumis sativus L. is an inhibitor of JAK2.


Referenze

1. Blaskovich, M.A., et al. 2003. Cancer Res. 63: 1270-1279. PMID: 12649187
2. Nefedova, Y., et al. 2005. Cancer Res. 65: 9525-9535. PMID: 16230418
3. Dziennis, S. and Alkayed, N.J. 2008. Rev Neurosci. 19: 341-361. PMID: 19145989
4. Lui, V.W., et al. 2009. Carcinogenesis. 30: 2085-2094. PMID: 19843642

Stato fisico :
Solid
Derivato da :
Cucumis sativus L.
Solubilità :
Soluble in DMSO (10 mM), and ethanol (20 mM).
CONSERVAZIONE :
Desiccate at -20° C
Punto di ebollizione :
698.32° C at 760 mmHg (Predicted)
Densità :
1.26 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.59 (Predicted)
IC50 :
HL-60: IC50 = 0.1 nM (human); U-937: IC50 = 0.3 nM (human); HT-1080: IC50 = 0.47 nM (human); HT-29: IC50 = 190 nM (human); Integrin αL: IC50 = 950 nM (human)
Valori pK :
pKa: 8.51 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
RTECS :
RC6200000
PubChem CID :
Numero MDL :
MFCD09971044
Numero EC :
218-736-8
SMILES :

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Cucurbitacin I (CAS 2222-07-3)  Citazioni prodotti

Vedi quanti altri hanno usato Cucurbitacin I (CAS 2222-07-3). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a9 di 9 totali

PMID: # 34249005  Molina, MS.|Hoffman, EA.|Stokes, J.|Kummet, N.|Smith, KA.|Baker, F.|Zúñiga, TM.|Simpson, RJ.|Katsanis, E.| et al. 2021. Front Immunol. 12: 699128.

PMID: # 30776726  Panek, CA.|Bruballa, AC.|Pineda, GE.|De Brasi, C.|Fernández-Brando, RJ.|Mejías, MP.|Ramos, MV.|Palermo, MS.| et al. 2019. Mol. Immunol. 108: 23-33.

PMID: # 24733676  Kim, HJ. et al. 2015. Archives of pharmacal research. 38: 290-8.

PMID: # 25571964  Zhang, N. et al. 2015. Oncology reports. 33: 1493-8.

PMID: # 24858077  Kim, HJ. et al. 2014. Chemico-biological interactions. 219: 1-8.

PMID: # 25047252  Wu, T. et al. 2014. 66: 3129-39.

PMID: # 22450744  Ozenne, P. et al. 2013. Oncogene. 32: 1050-8.

PMID: # 31501481  Sci Rep. 12884.

PMID: # 30214592  Oncol Lett. 16: 4577-4585.

Ciatazioni 1 a9 di 9 totali
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