Combretastatin A4 Phosphate Disodium Salt (CAS 168555-66-6)

Combretastatin A4 Phosphate Disodium Salt is the salt form of Combretastatin A4, a phosphorylated microtubule depolymerizing molecule which induces tumor necrosis by regression of unstable nascent tumor neo-vessels. Studies suggest that Combretastatin A4 Phosphate Disodium Salt selectively inhibits endothelial tumor cells via disrupting VE-cadherin (vascular endothelial-cadherin). In addition, Combretastatin A4 Phosphate Disodium Salt can increase the permeability of endothelial cells while inhibiting their migration and suppress capillary tube formation via disruption of VE-cadherin. Furthermore, Combretastatin A4 Phosphate Disodium Salt can change the morphology of endothelial cells by altering their tubulin cytoskeleton.

Referenze

1. West, C.M. and Price, P. 2004. Anticancer Drugs. 15: 179-187. PMID: 15014350
2. Young, S.L., et al. 2004. Expert Opin Investig Drugs. 13: 1171-1182. PMID: 15330748
3. Vincent, L., et al. 2005. J. Clin. Invest. 115: 2992-3006. PMID: 16224539
4. Nagaiah, G. and Remick, S.C. 2010. Future Oncol. 6: 1219-1228. PMID: 20799867