CKR-2 Antibody (48607.121): sc-57068

CKR-2 Antibody (48607.121) is a mouse monoclonal IgG2b antibody that detects CKR-2 protein of human origin by flow cytometry (FCM). Anti-CKR-2 antibody (48607.121) is available as the non-conjugated format. CKR-2, also known as C-C chemokine receptor type 2, plays a crucial role in immune response by mediating chemotaxis of monocytes and T cells to sites of inflammation, which is vital for effective immune surveillance and response to pathogens. This 374 amino acid multi-pass membrane protein is expressed in two isoforms, CKR-2A and CKR-2B, both serving as receptors for various chemokines, including monocyte chemoattractant protein-1 (MCP-1) and MCP-3. Upon binding to these ligands, CKR-2 influences intracellular calcium levels and initiates signal transduction pathways essential for migration and activation of immune cells. CKR-2 receptor has been implicated in facilitating viral infections, highlighting a dual role in both immune response and potential pathogenesis. Understanding CKR-2′s function and interactions with other proteins is critical for developing therapeutic strategies targeting inflammatory diseases and viral infections.

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CKR-2 Antibody (48607.121) References:

1. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2.  |  Schweickart, VL., et al. 1994. Genomics. 23: 643-50. PMID: 7851893
2. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.  |  Feng, Y., et al. 1996. Science. 272: 872-7. PMID: 8629022
3. Identification of a major co-receptor for primary isolates of HIV-1.  |  Deng, H., et al. 1996. Nature. 381: 661-6. PMID: 8649511
4. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.  |  Dragic, T., et al. 1996. Nature. 381: 667-73. PMID: 8649512
5. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1.  |  Alkhatib, G., et al. 1996. Science. 272: 1955-8. PMID: 8658171
6. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.  |  Choe, H., et al. 1996. Cell. 85: 1135-48. PMID: 8674119
7. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.  |  Doranz, BJ., et al. 1996. Cell. 85: 1149-58. PMID: 8674120
8. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC.  |  Baba, M., et al. 1997. J Biol Chem. 272: 14893-8. PMID: 9169459

The preferred CKR-2B antibody is CKR-2B Antibody (A-11): sc-74490.