CDw75/ST6GAL1 Antibody (LN-1): sc-6263

ST6GAL1 Antibody (LN-1) is a mouse monoclonal IgM antibody that detects ST6GAL1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-ST6GAL1 antibody (LN-1) is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC), providing flexibility for different experimental needs. ST6GAL1, also known as CD75, plays a crucial role in the biosynthesis of sialylated glycoproteins and glycolipids, which are essential for cell-cell interactions and signaling. Located primarily in the Golgi apparatus, ST6GAL1 catalyzes the transfer of sialic acid to galactose-containing carbohydrate acceptors, leading to the formation of cell surface antigens such as CDw75. This process is vital for modulating immune responses and maintaining cellular communication. CDw75 expression is often upregulated in B-cell leukemias, indicating potential involvement in tumorigenesis and metastasis. ST6GAL1 (LN-1) antibody enables researchers to gain insights into the functional dynamics of sialylation in various biological contexts, particularly in the study of immune cell behavior and cancer biology.

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CDw75/ST6GAL1 Antibody (LN-1) References:

1. The B lymphocyte surface antigen CD75 is not an alpha-2,6-sialyltransferase but is a carbohydrate antigen, the production of which requires the enzyme.  |  Munro, S., et al. 1992. Cell. 68: 1003. PMID: 1547499
2. Cell cycle-dependent regulation of CDw75 (beta-galactoside alpha-2,6-sialyltransferase) on human B lymphocytes.  |  Erikstein, BK., et al. 1992. Eur J Immunol. 22: 1149-55. PMID: 1577059
3. Characteristics of two CD75-related cell-surface expressed antigens of human lymphocytes.  |  Eichler, W. 2007. Mol Immunol. 44: 2047-55. PMID: 17067678
4. The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase, CD75, on B cells.  |  Stamenkovic, I., et al. 1991. Cell. 66: 1133-44. PMID: 1717156
5. The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase.  |  Bast, BJ., et al. 1992. J Cell Biol. 116: 423-35. PMID: 1730763
6. Regulation of ST6GAL1 sialyltransferase expression in cancer cells.  |  Dorsett, KA., et al. 2021. Glycobiology. 31: 530-539. PMID: 33320246
7. Two new monoclonal antibodies, Lym-1 and Lym-2, reactive with human B-lymphocytes and derived tumors, with immunodiagnostic and immunotherapeutic potential.  |  Epstein, AL., et al. 1987. Cancer Res. 47: 830-40. PMID: 3542194
8. ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.  |  Scott, E., et al. 2023. J Pathol. 261: 71-84. PMID: 37550801
9. ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression.  |  Bhalerao, N., et al. 2023. JCI Insight. 8: PMID: 37643018
10. CDw75 antigen expression in breast lesions.  |  Reed, W., et al. 1993. Pathol Res Pract. 189: 394-8. PMID: 7688897
11. CDw75 antigen expression in human gastric carcinoma and adjacent mucosa.  |  David, L., et al. 1993. Cancer. 72: 1522-7. PMID: 8348485
12. HB4 antibody recognizes a carbohydrate structure on lymphocyte surface proteins related to HB6, CDw75, and CD76 antigens.  |  De Lau, WB., et al. 1993. J Immunol. 150: 4911-9. PMID: 8496593

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CDw75/ST6GAL1 Antibody (LN-1) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-CDw75/ST6GAL1 Antibody (LN-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CDw75/ST6GAL1 Antibody (LN-1) Specifications

Alternate Product Name: CDw75

Product Clone Name: LN-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: CDw75

Epitope Species: human

Product Reactivity/Detection: CDw75

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for CDw75/ST6GAL1 Antibody (LN-1): FITC: Fluoroscein, PE: Phycoerythrin