cDPCP CAS: 106343-54-8
MF: C5H11Cl2PtN3
MW: 379.14
A tumor cell permeable, potent platinum-based antineoplastic agent.

cDPCP (CAS 106343-54-8)

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Nomi alternativi: Pyriplatin
Applicazione: cDPCP is a tumor cell permeable, potent platinum-based antineoplastic agent
Numero CAS: 106343-54-8
Purezza: ≥95%
Peso molecolare: 379.14
Formula molecolare: C5H11Cl2PtN3
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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cDPCP is a tumor cell permeable, potent platinum-based antineoplastic agent. cDPCP is a cationic monofunctional platinum(II) complex with unique chemical and biological properties. cDPCP binds covalently to only a single DNA base (the N7 atom of a single guanosine residue), and forms monofunctional rather than bifunctional lesions in DNA.


Referenze

Lovejoy, K. S. et al., cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects Proc. Natl. Acad. Sci. USA 105, 8902-8907, (2008); Hollis, L.S., et al,, Chemical and biological properties of a new series of cis-diammineplatinum(II) antitumor agents containing three nitrogen donors: cis-[Pt(NH3)2(N-donor)Cl] J. Med. Chem. 32, 128-136, (1989)

Stato fisico :
Solid
Solubilità :
Soluble in Water: >10 mg/mL
CONSERVAZIONE :
Store at 4° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
1
PubChem CID :
SMILES :
C1=CC=NC=C1.N.N.[Cl-].Cl[Pt]

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