CD46 Antibody (E4.3): sc-7634

CD46 Antibody (E4.3) is a mouse monoclonal IgG2a kappa light chain antibody that detects CD46 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-CD46 antibody (E4.3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD46, also known as membrane cofactor protein (MCP), is a crucial transmembrane glycoprotein that plays a significant role in regulating the complement system, which is vital for immune response and inflammation. CD46 exists as a non-disulfide-linked dimer and is primarily located on the surface of immune cells such as thymocytes, T cells, B cells, monocytes, and granulocytes, as well as on endothelial and epithelial cells. CD46 on these cells is essential for preventing complement-mediated damage to self-tissues, as CD46 acts as a cofactor for the degradation of C3b and C4b by the serine protease factor I. This regulatory function is primarily attributed to the complement control protein repeats (CCPs) within CD46′s structure, particularly CCP1-4, which are critical for activity. Additionally, CD46 serves as a high-affinity receptor for pathogens such as the measles virus and human herpes virus, highlighting CD46′s importance in both immune regulation and viral pathogenesis. Mouse cells express CRRY, a functional ortholog of human decay-accelerating factor (DAF or CD55) and membrane cofactor protein (MCP or CD46), further emphasizing the evolutionary conservation of CD46′s function across species.

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CD46 Antibody (E4.3) References:

1. CD46 plasticity and its inflammatory bias in multiple sclerosis.  |  Ni Choileain, S. and Astier, AL. 2011. Arch Immunol Ther Exp (Warsz). 59: 49-59. PMID: 21267793
2. CD46 in innate and adaptive immunity: an update.  |  Cardone, J., et al. 2011. Clin Exp Immunol. 164: 301-11. PMID: 21488871
3. CD46 Genetic Variability and HIV-1 Infection Susceptibility.  |  Serrano-Rísquez, C., et al. 2021. Cells. 10: PMID: 34831317
4. CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment.  |  Li, J., et al. 2023. J Exp Clin Cancer Res. 42: 61. PMID: 36906664
5. Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy.  |  Bidkar, AP., et al. 2023. Clin Cancer Res. 29: 1916-1928. PMID: 36917693
6. Immunologic and Genetic Contributors to CD46-Dependent Immune Dysregulation.  |  Meyer, BJ., et al. 2023. J Clin Immunol. 43: 1840-1856. PMID: 37477760
7. CD46 expression in the central nervous system of male and female pubescent mice.  |  Esposito, P., et al. 2023. J Neuroimmunol. 385: 578234. PMID: 37944208
8. CD46-ADC Reduces the Engraftment of Multiple Myeloma Patient-Derived Xenografts.  |  VanWyngarden, MJ., et al. 2023. Cancers (Basel). 15: PMID: 38001595
9. CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma.  |  Wadhwa, A., et al. 2024. Clin Cancer Res. 30: 1009-1021. PMID: 38109209
10. Soluble CD46 as a diagnostic marker of hepatic steatosis.  |  Bitterer, F., et al. 2024. EBioMedicine. 104: 105184. PMID: 38838471

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD46 Antibody (E4.3) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-CD46 Antibody (E4.3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD46 Antibody (E4.3) Specifications

Alternate Product Name: Membrane Cofactor Protein (MCP)

Product Clone Name: E4.3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: CD46

Epitope Species: human

Product Reactivity/Detection: CD46

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for CD46 Antibody (E4.3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred CD46 antibody is CD46 Antibody (C-10): sc-166159.