CD45 Inibitori per le analisi funzionali delle risposte cellulari a CD45
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CD45 has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45 are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5 and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45, while the intracellular domain is conserved. CD45 functions as a phosphotyrosine phosphatase, a vital component for efficient tyrosine phosphorylation induction by the TCR/CD3 complex. The tyrosine phosphatase activity of CD45 is contained within the conserved intracellular domain. Src and Syk family protein tyrosine kinases are utilized by the TCR/CD3 complex to initiate signaling cascades. Several members of these two families, including Lck, Fyn and ZAP-70, have been implicated as physiological substrates of CD45.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
I would like to use CD45 Antibody (3H1363): sc-70699 for IP applications. Does this antibody come pre-conjugated to agarose?
Richiesta da: Trav11
Thank you for your question. Please send an email request to [email protected] for primary antibody conjugation not listed on our website. Also, you may want to consider using CD45 (35-Z6): sc-1178 as it is currently available conjugated to agarose, HRP, FITC, PE, Alexa Fluor 488, and Alexa Fluor 647. If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Risposta da: Technical Support 3
Data di pubblicazione: 2017-01-11
What is the recommended positive control for CD45 Antibody (3H1363): sc-70699?
Richiesta da: Trav11
Thank you for your question. For CD45 Antibody (3H1363): sc-70699, there are several options for positive controls, such as Jurkat Whole Cell Lysate (sc-2204) or HL-60 Whole Cell Lysate (sc-2209). If you have any further questions or concerns, or would like to know additional positive controls for sc-70699, please contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
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