Caspase-3 Inhibitor Inibitore Caspase-3 Inhibitor is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10.

Caspase-3 Inhibitor Inibitore (CAS 210344-95-9)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 113ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Caspase-3 Inhibitor Inibitore is rated 5.0 out of 5 by 1.
loading
5
1
4
0
3
0
2
0
1
0
Nomi alternativi: Z-DEVD-FMK
Applicazione: Caspase-3 Inhibitor is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
Numero CAS: 210344-95-9
Purezza: ≥90% (solid)
Peso molecolare: 668.66
Formula molecolare: C30H41FN4O12
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
loading

Caspase-3 inhibitor (Z-DEVD-FMK ) is a cell-permeable, potent, and irreversible inhibitor of caspase-3, caspase-6, caspase-7, caspase-8 and caspase-10. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).


Referenze

1. Schlegel, J. et al. 1996. J. Biol. Chem. 271(4): 1841-1844. PMID: 8567626
2. Nicholson, D.W. 1996. Nat. Biotechnol. 14(3): 297-301. PMID: 9630889
3. Masuda, Y. et al. 1997. Biochem. Biophys. Res. Commun. 234(3): 641-645. PMID: 9175767
4. Thornberry, N.A. and Lazebnik, Y. 1998. Science. 281(5381): 1312-1316. PMID: 9721091
5. Brockstedt, E., et al., 1998. The Journal of biological chemistry. 273(43): 28057-64. PMID: 9774422
6. Henshall, D C., et al., 2000. Journal of neurochemistry. 74(3): 1215-23. PMID: 10693954
7. Kugawa, F., et al., 2000. Biological & pharmaceutical bulletin. 23(8): 930-5. PMID: 10963298
8. Nagarajah, N.S. et al. 2004. Mol. Cancer. 3(1): 38. PMID: 15613236
9. Cervantes, J. et al. 2008. Cell. Microbiol. 10(1): 41-52. PMID: 17662073

Utilizzo :
Pretreatment with an esterase is required when using with purified native or recombinant enzyme.

We recommend a final concentration of 2-10µM for inhibiting caspase activity in cell culture. The optimal doses may vary for different cells and culture conditions.
Stato fisico :
Solid
Sequenza :
Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-FMK
Solubilità :
Soluble in DMSO (13.37 mg/ml).
CONSERVAZIONE :
Store at -20° C
Punto di ebollizione :
~914.2° C at 760 mmHg (Predicted)
Densità :
~1.3 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.51 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
SMILES :
CC(C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](CCC(=O)OC)NC(=O)[[email protected]](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

CERTIFICATO DI ANALISI

Adobe Acrobat Reader necessario per una visualizzazione affidabile,
stampa e commenta sui documenti PDF

Caspase-3 Inhibitor Inibitore (CAS 210344-95-9)  Citazioni prodotti

Vedi quanti altri hanno usato Caspase-3 Inhibitor Inibitore (CAS 210344-95-9). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 52 totali

PMID: # 33618169  Wu, SW.|Su, CH.|Ho, YC.|Huang-Liu, R.|Tseng, CC.|Chiang, YW.|Yeh, KL.|Lee, SS.|Chen, WY.|Chen, CJ.|Li, YC.|Lee, CY.|Kuan, YH.| et al. 2021. Ecotoxicol Environ Saf. 213: 112062.

PMID: # 30904799  Zhao, W.|Li, H.|Hou, Y.|Jin, Y.|Zhang, L.| et al. 2019. World Neurosurg. 127: e346-e352.

PMID: # 31189945  Chambers, JS.|Brend, T.|Rabbitts, TH.| et al. 2019. Sci Rep. 9: 8553.

PMID: # 30795621  Nováková, J.|Talacko, P.|Novák, P.|Vališ, K.| et al. 2019. Cells. 8:

PMID: # 30692621  Choi, YJ. et al. 2019. Nat. Immunol. 20: 276-287.

PMID: # 31035052  Huang, WC.|Gu, PY.|Fang, LW.|Huang, YL.|Lin, CF.|Liou, CJ.| et al. 2019. Phytomedicine. 61: 152852.

PMID: # 30161272  Chen, XB.|Li, W.|Chu, AX.| et al. 2019. J. Cell. Biochem. 120: 470-480.

PMID: # 31313541  Bishayee, K.|Habib, K.|Sadra, A.|Huh, SO.| et al. 2019. Cell. Physiol. Biochem. 53: 258-280.

PMID: # 29670107  Parida, PK. et al. 2018. Cell Death Dis. 9: 448.

PMID: # 30131570  Lee, BS.|Kim, YS.|Kim, HJ.|Kim, DH.|Won, HR.|Kim, YS.|Kim, CH.| et al. 2018. Sci Rep. 8: 12520.

Ciatazioni 1 a10 di 52 totali
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 122ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;