Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Botulism is a rare but serious paralytic illness caused by a nerve toxin, which is produced by the anaerobic bacillus Clostridium botulinum. This neuromuscular disorder occurs through a complex series of molecular events, ultimately ending with the arrest of acetylcholine (Ach) release and flaccid paralysis. Botulinum neurotoxin type E, also referred to as BoNT/E, cleaves synaptosomal-associated protein (SNAP-25) at the C-terminal domain releasing a 26-mer peptide. This peptide product may act as an excitation-secretion uncoupling peptide (ESUP) to inhibit vesicle fusion which causes a long (at least 3 weeks) halt of Ach release after the cleavage of SNAP-25. BoNT/E also inhibits glutamate release and blocks the spike activity of pyramidal neurons. BoNT/E treatment reduces both focal and generalized kainic acid-induced seizures and also prevents the neuronal loss and long-term cognitive deficits that are associated with these seizures.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn