(-)-Bicuculline methobromide CAS: 73604-30-5
MF: C21H20BrNO6
MW: 462.29
An N-methylated derivative of the GABAA antagonist bicuculline.

(-)-Bicuculline methobromide (CAS 73604-30-5)

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Applicazione: (−)-Bicuculline methobromide is an N-methylated derivative of the GABAA antagonist bicuculline
Numero CAS: 73604-30-5
Purezza: ≥98%
Peso molecolare: 462.29
Formula molecolare: C21H20BrNO6
Informazioni supplementari: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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(-)-Bicuculline methobromide is the N-methyl methobromide salt of bicuculline, a competitive antagonist of the GABAA receptor. The N-methyl derivatives (-)-Bicuculline methobromide and (-)-Bicuculline methiodide (sc-200485) are more water-soluble and stable than the parent compound and have been employed as specific GABAA receptor antagonists analogous in function to the free base of bicuculline. Non-GABAA-specific behavior divergent from the activity of the parent compound has been reported with (-)-Bicuculline methobromide and (-)-Bicuculline methiodide. Both compounds are observed to block afterhyperpolarizations mediated by Ca2+-activated K+ channels in dopaminergic neurons.


Referenze

1. Hill, D.R. and Bowery, N.G. 1981. Nature. 290: 149-152. PMID: 6259535
2. Seutin, V., et al. 1999. Trends Pharmacol. Sci. 20: 268-270. PMID: 10390643

Aspetto :
Powder
Stato fisico :
Solid
Solubilità :
Soluble in water (25 mg/ml), chloroform, and ethanol.
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
227-230° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
SMILES :
C[N+]1(CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3)C.[Br-]

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(-)-Bicuculline methobromide (CAS 73604-30-5)  Citazioni prodotti

Vedi quanti altri hanno usato (-)-Bicuculline methobromide (CAS 73604-30-5). Clicca sulla voce per laccesso a PubMed .

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PMID: # 30689790  den Boon, FS.|de Vries, T.|Baelde, M.|Joëls, M.|Karst, H.| et al. 2019. Endocrinology. 160: 791-802.

PMID: # 27460963  Karst, H.|Joëls, M.| et al. 2016. Neuropharmacology. 110: 175-180.

PMID: # 32882227  Neuropharmacology. 108294.

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