Benzylimidazole CAS: 4238-71-5
MF: C10H10N2
MW: 158.2
An inducer of various cytochrome P-450 isozymes and inhibitor of thromboxane A2 synthase.

Benzylimidazole (CAS 4238-71-5)

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Applicazione: Benzylimidazole is an inducer of various cytochrome P-450 isozymes and inhibitor of thromboxane A2 synthase
Numero CAS: 4238-71-5
Purezza: ≥98%
Peso molecolare: 158.2
Formula molecolare: C10H10N2
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Benzylimidazole is commonly used as a procarcinogenic or mutagenic compound. Benzylimidazole was found to induce various cytochrome P-450 (CYP) isozymes including, CYP1A, CYP2B1, CYP3A2 and CYP4A11. The compound has also decreased plasma triglyceride levels and has been a potent inducer of rat liver enzymes. Benzylimidazole has been observed to stimulate three distinct forms of UDP-glucuronosyltransferase in male Wistar rats. In addition, Benzylimidazole has been shown to inhibit TXA Synthase (thromboxane A2 synthase) and to have strong cardiotonic activity similar to the cardiac glycosides, including the absence of effects on rate and resistance to adrenergic beta blockers.


Referenze

1. Tuttle, R.S., et al. 1975. J. Pharmacol. Exp. Ther. 194: 624-632. PMID: 1159635
2. Lynch, T.J., et al. 1985. Biochem. Pharmacol. 34: 1515-1522. PMID: 2986650
3. Magdalou, J., et al. 1988. Biochem. Pharmacol. 37: 3297-3304. PMID: 2840913
4. Mori, Y., et al. 1993. Mutat. Res. 302: 129-133. PMID: 7684507
5. Mori, Y., et al. 2001. Mutagenesis. 16: 479-486. PMID: 11682638

Stato fisico :
Solid
Solubilità :
Soluble in methanol, acetone, DMSO, ethanol, dilute acids (freely soluble), and buffers of pH>6.0 (freely soluble). Insoluble in water.
CONSERVAZIONE :
Store at room temperature
Punto di scioglimento :
68-70° C (lit.)
Punto di ebollizione :
310° C (lit.)
Densità :
1.04 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.58 (Predicted)
IC50 :
Cytochrome P450 11B1: IC50 = 135 nM (human); Thromboxane-A synthase: IC50 = 602 nM (human); Cytochrome P450 19A1: IC50 = 150 nM (human); Trypanosoma cruzi: EC5050 = 35 µM (Trypanosoma cruzi)
Valori pK :
pKb: 6.79 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
Numero MDL :
MFCD00005296
Numero EC :
224-200-4
Registro Beilstein :
114571
SMILES :
C1=CC=C(C=C1)CN2C=CN=C2

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