Molecular structure of BAY 11-7085, CAS Number: 196309-76-9
BAY 11-7085 (CAS 196309-76-9)
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Alternate Names:
BAY 11-7085 is known as an NF-κB activation and IκBα phosphorylatiion inhibitor.
Application:
BAY 11-7085 is an inhibitor of NF-κB activation and IκBα phosphorylatiion with potent anti-inflammatory activity.
CAS Number:
196309-76-9
Purity:
≥99%
Molecular Weight:
249.33
Molecular Formula:
C13H15NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BAY 11-7085 is an inhibitor of NF-κB activation and TNFα-induced phosphorylation. BAY 11-7085 has demonstrated potent anti-inflammatory action. BAY 11-7085 is shown to decrease the lipopolysaccharide-induced production of cytokines IL-1beta and IL-8, and the chemokine CCL17. BAY 11-7085 studies also suggests it has a role in lessening the effect of neuronal injury-induced glial apoE secretion. In rats, BAY 11-7085 is shown to reduce silica-induced inflammation and collagen deposition. Additionally, BAY 11-7085 is able to reversibly activate MAP kinases and stimulate apoptosis.
BAY 11-7085 (CAS 196309-76-9) References
- Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis. | Koedel, U., et al. 2000. J Infect Dis. 182: 1437-45. PMID: 11023466
- Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E. | Petegnief, V., et al. 2001. Neuroscience. 104: 223-34. PMID: 11311545
- 15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. | Relic, B., et al. 2004. J Biol Chem. 279: 22399-403. PMID: 15004016
- Induction of apoptosis in p53-deficient L1210 cells by an I-kappa-B-alpha-inhibitor (Bay 11-7085) via a NF-kappa-B-independent mechanism. | Cory, AH. and Cory, JG. 2005. Adv Enzyme Regul. 45: 85-93. PMID: 16129475
- NF-kappaB signaling blockade by Bay 11-7085 during early cardiac morphogenesis induces alterations of the outflow tract in chicken heart. | Hernández-Gutierrez, S., et al. 2006. Apoptosis. 11: 1101-9. PMID: 16699956
- Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study. | Nasu, K., et al. 2007. Am J Physiol Endocrinol Metab. 293: E16-23. PMID: 16896168
- Cytotoxicity of NF-kappaB inhibitors Bay 11-7085 and caffeic acid phenethyl ester to Ramos and other human B-lymphoma cell lines. | Berger, N., et al. 2007. Exp Hematol. 35: 1495-509. PMID: 17889719
- Systemic inhibition of NF-kappaB activation protects from silicosis. | Di Giuseppe, M., et al. 2009. PLoS One. 4: e5689. PMID: 19479048
- Hirsutenone inhibits lipopolysaccharide-activated NF-kappaB-induced inflammatory mediator production by suppressing Toll-like receptor 4 and ERK activation. | Lee, CS., et al. 2010. Int Immunopharmacol. 10: 520-5. PMID: 20138154
- BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death. | Relic, B., et al. 2016. Oncotarget. 7: 23370-82. PMID: 26993765
- Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis. | Chang, LC., et al. 2018. Cancer Lett. 416: 124-137. PMID: 29274359
- Serum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death. | Relic, B., et al. 2018. Oncotarget. 9: 35830-35843. PMID: 30533198
- Repurposing Kinase Inhibitor Bay 11-7085 to Combat Staphylococcus aureus and Candida albicans Biofilms. | Escobar, IE., et al. 2021. Front Pharmacol. 12: 675300. PMID: 34025434
- Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. | Pierce, JW., et al. 1997. J Biol Chem. 272: 21096-103. PMID: 9261113
Inhibitor of:
β-defensin 18, AOAH, BY080835, C. abortus LPS, C230096C10Rik, caspase-11, CLEC-6A, DHRS6, EFO2, EG240921, EG624439, EG624584, EG637776, FAM159A, FHL-1, GS188, HAS2, HRF, IκB-γ, IκB-ζ, IFN-α16, IFT122, IKK beta, IL-18, KIAA0020, KIAA0664, LOC387856_AI836003, LOC390937_EG232974, LYSMD4, MALL, NAIP5, NAIP6, NALP4C, NALP4E, NELL2, nemo I, NF kappa B, NFRκB, Olfr56, SAA2, SCD1, Sialyltransferase 7E, ST2, THP, Tie-2, TLR9, TRIM, TRIM43A, Vmn1r113, and ZNF683.Activator of:
CLEC-2, IRAK-M, KLF16, mitochondrial ferritin, p100, PP2B-Aγ, SPNS2, Testican-1, TNFα-IP 2, TRABID, and ZNF721.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAY 11-7085, 10 mg | sc-202490 | 10 mg | $124.00 | |||
BAY 11-7085, 50 mg | sc-202490A | 50 mg | $526.00 |