Ambroxol hydrochloride CAS: 23828-92-4
MF: C13H18Br2N2O•HCl
MW: 414.6
An expectorant antioxidant and antiinflammatory agent.

Ambroxol hydrochloride (CAS 23828-92-4)

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Applicazione: An expectorant antioxidant and antiinflammatory agent
Numero CAS: 23828-92-4
Purezza: 98%
Peso molecolare: 414.6
Formula molecolare: C13H18Br2N2O•HCl
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Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effects. The antioxidant effects of Ambroxol are well demonstrated, where lipid peroxidation initiated by t-butyl hydroperoxide or doxorubicin is suppressed in the presence Ambroxol, and scavenging of hydroxyl radicals and cellular superoxide radical anions is also observed. Ambroxol produces antiinflammatory effects by blocking the expression of proinflammatory messengers, inhibiting the release of histamine from mast cells and the generation of cytokines and interleukins. Ambroxol hydrochloride is an inhibitor of Sodium Channel Protein.


Referenze

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4. Gibbs, B.F., et al. 1999. Inflamm. Res. 48: 86-93. PMID: 10202994
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7. Su, X., et al. 2004. Intensive Care Med. 30: 133-140. PMID: 14504727
8. Beeh, K.M., et al. 2008. Eur. J. Med. Res. 13: 557-562. PMID: 19073395
9. Malerba, M., 2008. Expert Opin Drug Metab Toxicol. 4: 1119-1129. PMID: 18680446

Aspetto :
Crystalline powder
Stato fisico :
Solid
Solubilità :
Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether.
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
>235° C (dec.)
IC50 :
tetrodotoxin (TTX)-resistant channels: IC50 = 35.2 µM; TTX-sensitive subtypes: IC50 = 111.5 µM
Valori pK :
pKb: 8.69
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
GV8423000
PubChem CID :
108013
Indice Merck :
14: 386
Numero MDL :
MFCD00078932
Numero EC :
242-500-3
SMILES :
C1CC(CCC1NCC2=CC(=CC(=C2N)Br)Br)O.Cl

Download SDS (MSDS)

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