AM-404 (CAS 198022-70-7)

Utilizzo :

Stable for up to one year after receipt when stored at -20°C. Solutions are stable for up to 3 months when stored at -20°C under an inert atmosphere of nitrogen or argon

Stato fisico :

Solid

Solubilità :

Soluble in DMSO (50 mM), ethanol (50 mM), water (< 50 ug/ml at 25° C), ethanol:PBS(pH 7.2, 1:3) (0.25 mg/ml), and DMF (50 mg/ml).

Conservazione :

Store at -20° C

Densità :

~1.0 g/cm³ (Predicted)

Indice di rifrazione :

n²⁰_D 1.56

IC50 :

TRPV1: EC₅₀50 = 0.04 µM; Inhibit anandamide transport into the neuronal C6 glioma cells: IC₅₀ = 10 µM; Inhibit anandamide transport into the non-neuronal rat RBL-2H3 cells: IC₅₀ = 11 µM; FAAH: IC₅₀ = 5.9 µM; CB1 receptor : IC₅₀ = 1.76 µM; CB2 receptor: IC₅₀ >1 µM

Dati Ki :

Cannabinoid CB1 receptor: K_i= 1760 nM (rat); Cannabinoid CB2 receptor: K_i= 1300 nM (human); Vanilloid receptor: K_i= >5000 nM (rat); Cannabinoid CB1 receptor: K_i= 1500 nM (human); Cannabinoid CB2 receptor: K_i= 13000 nM (mouse)

Valori pK :

pK_a: 10.11, pK_b: 1.70

WGK Germania :

1

RTECS :

JX3849500

PubChem CID :

Numero MDL :

MFCD03095721

SMILES :

CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)NC1=CC=C(C=C1)O