alpha Tubulin Antibody (6A204): sc-69969

α Tubulin Antibody (6A204) is a mouse monoclonal IgG1 antibody that specifically recognizes α Tubulin across a wide range of species, including human, mouse, rat, and others. α Tubulin monoclonal antibody (6A204) is raised against Sarkosyl-resistant ribbons derived from Strongylocentrotus purpuratus (sea urchin) sperm axonemes, which ensures specificity for α Tubulin in microtubules. α Tubulin, along with β Tubulin, forms the core of microtubule structure, a critical component of the cytoskeleton. Microtubules play an essential role in maintaining cell shape, facilitating intracellular transport, and enabling cell division, particularly during mitotic spindle formation. α Tubulin is involved in microtubule filament nucleation at the centrosome, where stabilization and organization into dynamic structures occur for proper cell function. Structurally, α Tubulin is a globular protein that, when bound with β Tubulin, forms a heterodimer polymerizing to form hollow, cylindrical microtubules. α Tubulin undergoes several important post-translational modifications, including tyrosination and detyrosination, which regulate microtubule stability and interactions with motor proteins such as kinesins and dyneins, critical for cellular transport and motility. Precise regulation of α Tubulin′s structure and modifications is essential for processes like cell division, ciliary movement, and neuronal signaling. α Tubulin (6A204) antibody serves as a valuable tool for studying microtubule structure and dynamics, along with their involvement in cellular processes across various species.

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alpha Tubulin Antibody (6A204) References:

1. Evolution of duplicated alpha-tubulin genes in ciliates.  |  Israel, RL., et al. 2002. Evolution. 56: 1110-22. PMID: 12144013
2. HDAC6 α-tubulin deacetylase: a potential therapeutic target in neurodegenerative diseases.  |  Li, G., et al. 2011. J Neurol Sci. 304: 1-8. PMID: 21377170
3. Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation.  |  Di Fulvio, S., et al. 2011. PLoS One. 6: e28563. PMID: 22174839
4. The structure of the complex between α-tubulin, TBCE and TBCB reveals a tubulin dimer dissociation mechanism.  |  Serna, M., et al. 2015. J Cell Sci. 128: 1824-34. PMID: 25908846
5. Epigenetic factors MeCP2 and HDAC6 control α-tubulin acetylation in cardiac fibroblast proliferation and fibrosis.  |  Tao, H., et al. 2016. Inflamm Res. 65: 415-26. PMID: 26975406
6. Phosphorylation state of Ser165 in α-tubulin is a toggle switch that controls proliferating human breast tumors.  |  Markovsky, E., et al. 2018. Cell Signal. 52: 74-82. PMID: 30176291
7. Microtubule regulation: Transcending the tenet of K40 acetylation.  |  Prokop, A. 2022. Curr Biol. 32: R126-R128. PMID: 35134360
8. Acetylated α-tubulin alleviates injury to the dendritic spines after ischemic stroke in mice.  |  Yang, C., et al. 2023. CNS Neurosci Ther. 29: 2327-2338. PMID: 36965035
9. Chlamydomonas alpha-tubulin is posttranslationally modified in the flagella during flagellar assembly.  |  L'Hernault, SW. and Rosenbaum, JL. 1983. J Cell Biol. 97: 258-63. PMID: 6863393
10. Formation and function of the Rbl2p-beta-tubulin complex.  |  Archer, JE., et al. 1998. Mol Cell Biol. 18: 1757-62. PMID: 9488492

The preferred alpha Tubulin antibody is alpha Tubulin Antibody (TU-02): sc-8035.