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ABT 751 | CAS 141430-65-1 | SCBT - Santa Cruz Biotechnology
ABT 751 CAS: 141430-65-1
MF: C18H17N3O4S
ABT 751 is an inhibitor of microtubule polymerization.

ABT 751 (CAS 141430-65-1)

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Nomi alternativi: N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide
Applicazione: ABT 751 is an inhibitor of microtubule polymerization
Numero CAS: 141430-65-1
Peso molecolare: 371.41
Formula molecolare: C18H17N3O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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ABT 751 is an inhibitor of microtubule polymerization that binds β-Tubulin on the colchine site. ABT 751 has been shown to block the cell cycle at G2M phase and induce apoptosis. Reproted to exhibit antitumor activity. Furthermore ABT 751 displays activity in cell lines resistant to vincristine, doxorubicin and cisplatin.


Referenze

Hande et al (2006) The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study. Clin.Cancer Res. 12 2834.

Stato fisico :
Solid
Solubilità :
Soluble in DMSO (100 nM), and ethanol (25 nM).
CONSERVAZIONE :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DB2734000
PubChem CID :
SMILES :
COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O

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CERTIFICATO DI ANALISI

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