9Z,11E,13E-Octadecatrienoic Acid CAS: 506-23-0
MF: C18H30O2
MW: 278.4
An inhibitor of DNA polymerases and topoisomerases.

9Z,11E,13E-Octadecatrienoic Acid (CAS 506-23-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 110ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Applicazione: 9Z,11E,13E-Octadecatrienoic Acid is an inhibitor of DNA polymerases and topoisomerases
Numero CAS: 506-23-0
Peso molecolare: 278.4
Formula molecolare: C18H30O2
Informazioni supplementari: This product is subject to an additional Dangerous Goods shipping charge.
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

9Z,11E,13E-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid makes up about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. In rats, α-ESA was metabolized and converted to conjugated linoleic acid (9Z,11E-CLA). It has shown potential as a tumor suppressor. In Caco-2 colon cancer cells, α-ESA triggered apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was triggered via lipid peroxidation. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 µM for different isoforms of the enzymes.


Referenze

1. Tsuzuki, T., et al. 2004. Carcinogenesis. 25: 1417-1425. PMID: 14963014
2. Mizushina, Y., et al. 2004. Lipids. 39: 977-983. PMID: 15691019
3. Yasui, Y., et al. 2005. Prostaglandins Leukot. Essent. Fatty Acids. 73: 113-119. PMID: 15961301

Formulazione :
a solution in methanol
Stato fisico :
Liquid
Solubilità :
Soluble in ethanol, DMSO, and DMF.
CONSERVAZIONE :
Store at -80° C
Punto di ebollizione :
~390.6° C at 760 mmHg
IC50 :
DNA polymerases and topoisomerases: IC50 = ~5-20 µM (different isoforms of the enzymes)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
Trasporto :
UN 1230, Class 3(6.1), Packing group II
PubChem CID :
Numero MDL :
MFCD05864023
SMILES :
CCCC/C=C/C=C/C=C\CCCCCCCC(=O)O

Download SDS (MSDS)

CERTIFICATO DI ANALISI

Adobe Acrobat Reader necessario per una visualizzazione affidabile,
stampa e commenta sui documenti PDF

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 117ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

La Santa Cruz Biotechnology, Inc. è un leader mondiale nello sviluppo di prodotti per il mercato della ricerca biomedica. Chiamaci al numero gratuito 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. Tutti i diritti riservati. "Santa Cruz Biotechnology", ed il logo Santa Cruz Biotechnology, Inc."Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", il logo San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", ed "EZ Touch" sono marchi registrati dalla Santa Cruz Biotechnology, Inc.
Tutti i marchi sono proprietà dei rispettivi proprietari.